Literature DB >> 12119272

Cyclic AMP and the reverse transformation reaction.

Theodore T Puck1, Patricia Webb, Robert Johnson.   

Abstract

Traditional methods for cancer treatment have been aimed at killing the cancer cells. Unfortunately this approach all too often is accompanied by harmful killing of normal cells. The present paper describes an experimental program in our laboratory in which cancer cells are treated so as to revert to normal cell behavior. This process, which we have named reverse transformation, appears to offer considerable hope in the treatment of a large number of malignancies.

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Year:  2002        PMID： 12119272     DOI： 10.1111/j.1749-6632.2002.tb04331.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  3 in total

1.  Cancer and epigenetic reversion--the fundamental role of redox.

Authors:  Eleni Papadopulos-Eleopulos; Barry A P Page; David Causer; Valendar F Turner; John M Papadimitriou
Journal:  Am J Pathol       Date:  2007-11       Impact factor: 4.307

2.  Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.

Authors:  Elise Meoli; Ioannis Bossis; Laure Cazabat; Manos Mavrakis; Anelia Horvath; Sotiris Stergiopoulos; Miriam L Shiferaw; Glawdys Fumey; Karine Perlemoine; Michael Muchow; Audrey Robinson-White; Frank Weinberg; Maria Nesterova; Yianna Patronas; Lionel Groussin; Jérôme Bertherat; Constantine A Stratakis
Journal:  Cancer Res       Date:  2008-05-01       Impact factor: 12.701

3.  Epigenetic reversion of breast carcinoma phenotype is accompanied by changes in DNA sequestration as measured by AluI restriction enzyme.

Authors:  Tone Sandal; Klara Valyi-Nagy; Virginia A Spencer; Robert Folberg; Mina J Bissell; Andrew J Maniotis
Journal:  Am J Pathol       Date:  2007-05       Impact factor: 4.307
  3 in total

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