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Literature DB >> 12118257

Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.

Inger Sundstrom-Poromaa¹, Deborah H Smith, Qi Hua Gong, Thomas N Sabado, Xinshe Li, Adam Light, Martin Wiedmann, Keith Williams, Sheryl S Smith.

Abstract

Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased.

Entities: Chemical Disease Species

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Year: 2002 PMID： 12118257 PMCID： PMC2887346 DOI： 10.1038/nn888

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

15 in total

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155 in total

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Authors: Brandon M Stell; Stephen G Brickley; C Y Tang; Mark Farrant; Istvan Mody
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Authors: Hong-Jin Shu; John Bracamontes; Amanda Taylor; Kyle Wu; Megan M Eaton; Gustav Akk; Brad Manion; Alex S Evers; Kathiresan Krishnan; Douglas F Covey; Charles F Zorumski; Joe Henry Steinbach; Steven Mennerick
Journal: Br J Pharmacol Date: 2012-04 Impact factor: 8.739

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Authors: Kelly R Wagoner; Cynthia Czajkowski
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