Literature DB >> 12117992

Alternative splicing of LYT1 transcripts in Trypanosoma cruzi.

Rebeca Manning-Cela1, Antonio González, John Swindle.   

Abstract

As a result of alternative trans splicing, three distinct LYT1 mRNAs are produced in Trypanosoma cruzi, two encoding the full-length LYT1 protein and the third encoding a truncated LYT1 protein lacking a possible signal sequence. Analysis of the three mRNAs in different developmental forms of the parasite revealed that the alternative processing events were regulated differently during the parasite life cycle.

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Year:  2002        PMID： 12117992      PMCID： PMC128154          DOI： 10.1128/IAI.70.8.4726-4728.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  12 in total

1.  Mutational analysis of 3' splice site selection during trans-splicing.

Authors:  H S Hummel; R D Gillespie; J Swindle
Journal:  J Biol Chem       Date:  2000-11-10       Impact factor: 5.157

2.  Unexpected point mutations activate cryptic 3' splice sites by perturbing a natural secondary structure within a yeast intron.

Authors:  J O Deshler; J J Rossi
Journal:  Genes Dev       Date:  1991-07       Impact factor: 11.361

3.  Maturation of polycistronic pre-mRNA in Trypanosoma brucei: analysis of trans splicing and poly(A) addition at nascent RNA transcripts from the hsp70 locus.

Authors:  J Huang; L H van der Ploeg
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

4.  Apparent generation of a segmented mRNA from two separate tandem gene families in Trypanosoma cruzi.

Authors:  A Gonzalez; T J Lerner; M Huecas; B Sosa-Pineda; N Nogueira; P M Lizardi
Journal:  Nucleic Acids Res       Date:  1985-08-26       Impact factor: 16.971

5.  Polycistronic transcripts in trypanosomes and their accumulation during heat shock: evidence for a precursor role in mRNA synthesis.

Authors:  M L Muhich; J C Boothroyd
Journal:  Mol Cell Biol       Date:  1988-09       Impact factor: 4.272

6.  Control of polyadenylation and alternative splicing of transcripts from adjacent genes in a procyclin expression site: a dual role for polypyrimidine tracts in trypanosomes?

Authors:  E Vassella; R Braun; I Roditi
Journal:  Nucleic Acids Res       Date:  1994-04-25       Impact factor: 16.971

7.  Accurate polyadenylation of procyclin mRNAs in Trypanosoma brucei is determined by pyrimidine-rich elements in the intergenic regions.

Authors:  N Schürch; A Hehl; E Vassella; R Braun; I Roditi
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272

8.  LYT1 protein is required for efficient in vitro infection by Trypanosoma cruzi.

Authors:  R Manning-Cela; A Cortés; E González-Rey; W C Van Voorhis; J Swindle; A González
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441

9.  Transcription of the intergenic regions of the tubulin gene cluster of Trypanosoma brucei: evidence for a polycistronic transcription unit in a eukaryote.

Authors:  M A Imboden; P W Laird; M Affolter; T Seebeck
Journal:  Nucleic Acids Res       Date:  1987-09-25       Impact factor: 16.971

10.  A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes.

Authors:  K R Matthews; C Tschudi; E Ullu
Journal:  Genes Dev       Date:  1994-02-15       Impact factor: 11.361
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  9 in total

Review 1.  trans and cis splicing in trypanosomatids: mechanism, factors, and regulation.

Authors:  Xue-hai Liang; Asaf Haritan; Shai Uliel; Shulamit Michaeli
Journal:  Eukaryot Cell       Date:  2003-10

2.  Molecular characterization of a human BRCA2 homolog in Leishmania donovani.

Authors:  Smita Misra; Mack Hall; Gautam Chaudhuri
Journal:  J Parasitol       Date:  2005-12       Impact factor: 1.276

Review 3.  Molecular mechanisms of host cell invasion by Trypanosoma cruzi.

Authors:  Conrad L Epting; Bria M Coates; David M Engman
Journal:  Exp Parasitol       Date:  2010-06-18       Impact factor: 2.011

4.  Trypanosoma cruzi: molecular characterization of an RNA binding protein differentially expressed in the parasite life cycle.

Authors:  Leticia Pérez-Díaz; María Ana Duhagon; Pablo Smircich; José Sotelo-Silveira; Carlos Robello; Marco Aurelio Krieger; Samuel Goldenberg; Noreen Williams; Bruno Dallagiovanna; Beatriz Garat
Journal:  Exp Parasitol       Date:  2007-03-27       Impact factor: 2.011

Review 5.  Molecular analysis of early host cell infection by Trypanosoma cruzi.

Authors:  Fernando Villalta; M Nia Madison; Yuliya Y Kleshchenko; Pius N Nde; Maria F Lima
Journal:  Front Biosci       Date:  2008-05-01

6.  Impairment of infectivity and immunoprotective effect of a LYT1 null mutant of Trypanosoma cruzi.

Authors:  M Paola Zago; Alejandra B Barrio; Rubén M Cardozo; Tomás Duffy; Alejandro G Schijman; Miguel A Basombrío
Journal:  Infect Immun       Date:  2007-10-15       Impact factor: 3.441

7.  Glyceraldehyde 3-phosphate dehydrogenase-telomere association correlates with redox status in Trypanosoma cruzi.

Authors:  Ricardo Pariona-Llanos; Raphael Souza Pavani; Marcelo Reis; Vincent Noël; Ariel Mariano Silber; Hugo Aguirre Armelin; Maria Isabel Nogueira Cano; Maria Carolina Elias
Journal:  PLoS One       Date:  2015-03-16       Impact factor: 3.240

8.  Identification of protein complex associated with LYT1 of Trypanosoma cruzi.

Authors:  C Lugo-Caballero; G Ballesteros-Rodea; S Martínez-Calvillo; Rebeca Manning-Cela
Journal:  Biomed Res Int       Date:  2013-03-17       Impact factor: 3.411

9.  Molecular Characterization of Trypanosoma cruzi Tc8.2 Gene Indicates Two Differential Locations for the Encoded Protein in Epimastigote and Trypomastigote Forms.

Authors:  Danielle Kian; César Armando Contreras Lancheros; Igor Alexandre Campos Damiani; Tamiris Zanforlin Olmos Fernandes; Phileno Pinge-Filho; Márcia Regina Machado dos Santos; José Franco da Silveira; Celso Vataru Nakamura; João Santana da Silva; Sueli Fumie Yamada-Ogatta; Lucy Megumi Yamauchi
Journal:  Korean J Parasitol       Date:  2015-08-25       Impact factor: 1.341
  9 in total

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