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Literature DB >> 12117898

Molecular pathogenesis of iron overload.

D Trinder¹, C Fox, G Vautier, J K Olynyk.

Abstract

Our current understanding of iron absorption under normal conditions is presented, together with an overview of the clinical disorders of iron overload and the molecular processes that contribute to increased iron deposition in iron overload. Recently, a number of new genes involved in iron metabolism have been identified which is allowing the molecular mechanisms of iron absorption to be elucidated.

Entities: Chemical

Mesh：

Substances：

Year: 2002 PMID： 12117898 PMCID： PMC1773304 DOI： 10.1136/gut.51.2.290

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

81 in total

1. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

Authors: M D Fleming; M A Romano; M A Su; L M Garrick; M D Garrick; N C Andrews
Journal: Proc Natl Acad Sci U S A Date: 1998-02-03 Impact factor: 11.205

2. A simple genetic test identifies 90% of UK patients with haemochromatosis. The UK Haemochromatosis Consortium.

Authors:
Journal: Gut Date: 1997-12 Impact factor: 23.059

3. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.

Authors: J N Feder; D M Penny; A Irrinki; V K Lee; J A Lebrón; N Watson; Z Tsuchihashi; E Sigal; P J Bjorkman; R C Schatzman
Journal: Proc Natl Acad Sci U S A Date: 1998-02-17 Impact factor: 11.205

4. HFE gene knockout produces mouse model of hereditary hemochromatosis.

Authors: X Y Zhou; S Tomatsu; R E Fleming; S Parkkila; A Waheed; J Jiang; Y Fei; E M Brunt; D A Ruddy; C E Prass; R C Schatzman; R O'Neill; R S Britton; B R Bacon; W S Sly
Journal: Proc Natl Acad Sci U S A Date: 1998-03-03 Impact factor: 11.205

5. Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria.

Authors: P C Adams; S Chakrabarti
Journal: Gastroenterology Date: 1998-02 Impact factor: 22.682

6. Characterisation of non-transferrin-bound iron (ferric citrate) uptake by rat hepatocytes in culture.

Authors: E Baker; S M Baker; E H Morgan
Journal: Biochim Biophys Acta Date: 1998-03-12

Review 7. Aceruloplasminemia.

Authors: J D Gitlin
Journal: Pediatr Res Date: 1998-09 Impact factor: 3.756

8. Mechanisms of ferric citrate uptake by human hepatoma cells.

Authors: D Trinder; E Morgan
Journal: Am J Physiol Date: 1998-08

9. Noninvasive prediction of fibrosis in C282Y homozygous hemochromatosis.

Authors: D Guyader; C Jacquelinet; R Moirand; B Turlin; M H Mendler; J Chaperon; V David; P Brissot; P Adams; Y Deugnier
Journal: Gastroenterology Date: 1998-10 Impact factor: 22.682

10. Functional expression cloning and characterization of SFT, a stimulator of Fe transport.

Authors: J A Gutierrez; J Yu; S Rivera; M Wessling-Resnick
Journal: J Cell Biol Date: 1997-11-17 Impact factor: 10.539

26 in total

1. Effect of hereditary haemochromatosis genotypes and iron overload on other trace elements.

Authors: Jeffrey M Beckett; Madeleine J Ball
Journal: Eur J Nutr Date: 2012-02-09 Impact factor: 5.614

2. Normal iron metabolism and the pathophysiology of iron overload disorders.

Authors: Chiang W Siah; John Ombiga; Leon A Adams; Debbie Trinder; John K Olynyk
Journal: Clin Biochem Rev Date: 2006-02

3. Analysis of HFE genes C282Y, H63D, and S65D in patients with hyperferritinemia from northeastern Brazil.

Authors: Gioconda Dias Rodrigues Leão; Juliana Mendonça Freire; Andrea Luciana Araújo Cunha Fernandes; Taissa Maria Moura de Oliveira; Nilma Dias Leão; Erica Aires Gil; Roberto Chaves de Vasconcelos; João Paulo da Silva Azevedo; Valéria Soraya de Farias Sales; Telma Maria de Araújo Moura Lemos; Marcos Dias Leão; Francisco Fernandes do Nascimento; James Farley Rafael Maciel; Rodrigo Villar de Freitas; Aldair de Souza Paiva; Geraldo Barroso Cavalcanti
Journal: J Clin Lab Anal Date: 2014-01-06 Impact factor: 2.352

Molecular pathogenesis of iron overload.

1. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

2. A simple genetic test identifies 90% of UK patients with haemochromatosis. The UK Haemochromatosis Consortium.

3. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.

4. HFE gene knockout produces mouse model of hereditary hemochromatosis.

5. Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria.

6. Characterisation of non-transferrin-bound iron (ferric citrate) uptake by rat hepatocytes in culture.

Review 7. Aceruloplasminemia.

8. Mechanisms of ferric citrate uptake by human hepatoma cells.

9. Noninvasive prediction of fibrosis in C282Y homozygous hemochromatosis.

10. Functional expression cloning and characterization of SFT, a stimulator of Fe transport.

1. Effect of hereditary haemochromatosis genotypes and iron overload on other trace elements.

2. Normal iron metabolism and the pathophysiology of iron overload disorders.

3. Analysis of HFE genes C282Y, H63D, and S65D in patients with hyperferritinemia from northeastern Brazil.

4. Myeloperoxidase acts as a source of free iron during steady-state catalysis by a feedback inhibitory pathway.

5. Mechanism of hypochlorous acid-mediated heme destruction and free iron release.

6. Meat intake and risk of hepatocellular carcinoma in two large US prospective cohorts of women and men.

7. Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis.

Review 8. Screening for hemochromatosis: patients with liver disease, families, and populations.

9. Impact of hydrogen peroxide-driven Fenton reaction on mouse oocyte quality.

10. Melatonin prevents hypochlorous acid-mediated cyanocobalamin destruction and cyanogen chloride generation.