Literature DB >> 12117610

In vivo temporal EPR imaging of the brain of rats by using two types of blood-brain barrier-permeable nitroxide radicals.

Hidekastu Yokoyama1, Osamu Itoh, Masaaki Aoyama, Heitaro Obara, Hiroaki Ohya, Hitoshi Kamada.   

Abstract

In vivo temporal EPR imaging was conducted on the brain of rats that received one of two kinds of blood-brain barrier-permeable nitroxide radicals via the tail vein-one is a water-soluble 3-hydroxymethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (hydroxymethyl-PROXYL); and the other is a non-water-soluble 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (PCAM). From temporal EPR imaging data, temporal changes in the distribution of the nitroxide radical in the cerebral cortex, striatum, and hippocampus in the brain were investigated. It was found that the half-lives of the three parts in the brain of hydroxymethyl-PROXYL are longer and their EPR signal intensities are greater than those of PCAM.

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Year:  2002        PMID： 12117610     DOI： 10.1016/s0730-725x(02)00491-5

Source DB:  PubMed          Journal:  Magn Reson Imaging        ISSN： 0730-725X            Impact factor:   2.546


  8 in total

1.  Heterogeneity of regional redox status and relation of the redox status to oxygenation in a tumor model, evaluated using electron paramagnetic resonance imaging.

Authors:  Keizo Takeshita; Kumiko Kawaguchi; Kaori Fujii-Aikawa; Megumi Ueno; Shoko Okazaki; Mitsuhiro Ono; Murali C Krishna; Periannan Kuppusamy; Toshihiko Ozawa; Nobuo Ikota
Journal:  Cancer Res       Date:  2010-05-04       Impact factor: 12.701

2.  Spontaneous skin damage and delayed wound healing in SOD1-deficient mice.

Authors:  Yoshihito Iuchi; Dipa Roy; Futoshi Okada; Noriko Kibe; Satoshi Tsunoda; Saori Suzuki; Motoko Takahashi; Hidekatsu Yokoyama; Jun Yoshitake; Seiji Kondo; Junichi Fujii
Journal:  Mol Cell Biochem       Date:  2010-03-30       Impact factor: 3.396

Review 3.  Oxidative stress imaging in live animals with techniques based on electron paramagnetic resonance.

Authors:  Martyna Elas; Kazuhiro Ichikawa; Howard J Halpern
Journal:  Radiat Res       Date:  2012-02-21       Impact factor: 2.841

4.  Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent.

Authors:  Fuminori Hyodo; Kai-Hsiang Chuang; Artem G Goloshevsky; Agnieszka Sulima; Gary L Griffiths; James B Mitchell; Alan P Koretsky; Murali C Krishna
Journal:  J Cereb Blood Flow Metab       Date:  2008-02-13       Impact factor: 6.200

5.  Kinetics of extracellular nitroxide radical and glutamate levels in the hippocampus of conscious rats: cautionary note to the application of nitroxide radical on clinical arena.

Authors:  Yuto Ueda; Hidekatsu Yokoyama; Jun Tokumaru; Taku Doi; Akira Nakajima
Journal:  Neurochem Res       Date:  2004-09       Impact factor: 3.996

6.  Merging Preclinical EPR Tomography with other Imaging Techniques.

Authors:  Michal Gonet; Boris Epel; Howard J Halpern; Martyna Elas
Journal:  Cell Biochem Biophys       Date:  2019-08-22       Impact factor: 2.194

Review 7.  In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques.

Authors:  Goran Bačić; Aleksandra Pavićević; Fabienne Peyrot
Journal:  Redox Biol       Date:  2015-11-14       Impact factor: 11.799

Review 8.  Imaging Reactive Oxygen Species-Induced Modifications in Living Systems.

Authors:  Giuseppe Maulucci; Goran Bačić; Lori Bridal; Harald Hhw Schmidt; Bertrand Tavitian; Thomas Viel; Hideo Utsumi; A Süha Yalçın; Marco De Spirito
Journal:  Antioxid Redox Signal       Date:  2016-06-01       Impact factor: 8.401
  8 in total

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