BACKGROUND AND PURPOSE: Cavities occasionally found within the hippocampus during routine clinical magnetic resonance imaging (MRI) studies are believed to be a normal variant reflecting fluid collection within the vestigial hippocampal sulcus. However, the lack of systematic studies defining objective criteria for such cavities has hampered further assessment of potential abnormalities within the hippocampus. This study assessed the detailed characteristics of hippocampal cavities in normal subjects using a new high-resolution MRI technique in an attempt to define objective criteria of normalcy. METHODS: A new high-resolution imaging technique, T2-reversed MRI on a high-field (3.0-T) system was used to image the hippocampus in 74 normal volunteers in 3 age groups (28 young, 24 middle, and 22 senior). RESULTS: Residual cavities in the vestigial hippocampal sulcus were resolved as single, crescent-shaped structures along the deep aspect of the vestigial hippocampal sulcus. The size of the cavities did not vary with age and never exceeded 1 mm in width and 3 mm in length. The frequency of detection, however, increased with age (21.4% [5/28] in the young, 25.0% [6/24] in the middle, and 36.4 [8/22] in the senior age group). CONCLUSION: The study established clear objective criteria for normal cavities within the hippocampus. These cavities likely represent physiological fluid collection within the vestigial hippocampal sulcus. Any cavity that does not meet these defined criteria should be considered potentially abnormal.
BACKGROUND AND PURPOSE: Cavities occasionally found within the hippocampus during routine clinical magnetic resonance imaging (MRI) studies are believed to be a normal variant reflecting fluid collection within the vestigial hippocampal sulcus. However, the lack of systematic studies defining objective criteria for such cavities has hampered further assessment of potential abnormalities within the hippocampus. This study assessed the detailed characteristics of hippocampal cavities in normal subjects using a new high-resolution MRI technique in an attempt to define objective criteria of normalcy. METHODS: A new high-resolution imaging technique, T2-reversed MRI on a high-field (3.0-T) system was used to image the hippocampus in 74 normal volunteers in 3 age groups (28 young, 24 middle, and 22 senior). RESULTS: Residual cavities in the vestigial hippocampal sulcus were resolved as single, crescent-shaped structures along the deep aspect of the vestigial hippocampal sulcus. The size of the cavities did not vary with age and never exceeded 1 mm in width and 3 mm in length. The frequency of detection, however, increased with age (21.4% [5/28] in the young, 25.0% [6/24] in the middle, and 36.4 [8/22] in the senior age group). CONCLUSION: The study established clear objective criteria for normal cavities within the hippocampus. These cavities likely represent physiological fluid collection within the vestigial hippocampal sulcus. Any cavity that does not meet these defined criteria should be considered potentially abnormal.
Authors: N Morakkabati-Spitz; J Gieseke; C Kuhl; G Lutterbey; M von Falkenhausen; F Traeber; O Zivanovic; H H Schild Journal: Eur Radiol Date: 2004-12-31 Impact factor: 5.315
Authors: A J Bastos-Leite; J H van Waesberghe; A L Oen; W M van der Flier; P Scheltens; F Barkhof Journal: AJNR Am J Neuroradiol Date: 2006 Nov-Dec Impact factor: 3.825
Authors: Nuschin Morakkabati-Spitz; Jürgen Gieseke; Christiane Kuhl; Götz Lutterbey; Marcus von Falkenhausen; Frank Träber; Tjoung-Won Park-Simon; Oliver Zivanovic; Hans H Schild Journal: Eur Radiol Date: 2005-10-14 Impact factor: 5.315
Authors: Kim Blom; Huiberdina L Koek; Yolanda van der Graaf; Maarten H T Zwartbol; Laura E M Wisse; Jeroen Hendrikse; Geert Jan Biessels; Mirjam I Geerlings Journal: Brain Imaging Behav Date: 2019-08 Impact factor: 3.978