| Literature DB >> 12116196 |
G Roks1, M Cruts, J J Houwing-Duistermaat, B Dermaut, S Serneels, L M Havekes, A Hofman, M M B Breteler, C Van Broeckhoven, C M van Duijn.
Abstract
The apolipoprotein E (APOE) gene is involved in lipid transport. A common polymorphism in this gene with the APOE*2, APOE*3, and APOE*4 alleles influences plasma levels of apolipoprotein E and cholesterol. Besides its role in lipid transport, the APOE*4 allele is a genetic risk factor for Alzheimer disease (AD). Recently, a polymorphism in the APOE promoter region was found to be involved in plasma apolipoprotein E levels and was found associated with AD. We studied the effect of this -491A/T promoter polymorphism on plasma apolipoprotein E levels and risk for AD in a population-based case-control study. We found that there was a modest but statistically significant effect of the -491A/T polymorphism on plasma apolipoprotein E levels independent of the APOE genotype. The lowest plasma levels were measured for the AA genotype, highest levels for the TT genotype, and intermediate levels for the heterozygotes. There was a small effect of the -491 AA genotype on AD risk that disappeared after adjusting for APOE genotypes. Our data suggest that the -491A/T polymorphism has an APOE genotype-independent effect on plasma apolipoprotein E levels but no APOE-independent effect on AD risk. Copyright 2002 Wiley-Liss, Inc.Entities:
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Year: 2002 PMID： 12116196 DOI： 10.1002/ajmg.10407
Source DB: PubMed Journal: Am J Med Genet ISSN： 0148-7299