Literature DB >> 12114763

Human Insulinomas: Clinical, Cellular, and Molecular Aspects.

Paul Komminoth1, Philipp U. Heitz, Jürgen Roth.   

Abstract

Insulinoma is the most frequently encountered functioning endocrine pancreatic tumor in humans. In this overview we summarize morphological and clinical features of insulinomas, report about the proinsulin-insulin conversion in normal and neoplastic B-cells, discuss the new classification, the criteria of malignancy, and the clonal composition of endocrine pancreatic tumors, and outline recent findings on the molecular pathology of these tumors.

Entities:  

Year:  1999        PMID： 12114763     DOI： 10.1007/bf02739769

Source DB:  PubMed          Journal:  Endocr Pathol        ISSN： 1046-3976            Impact factor:   3.943


  54 in total

1.  Functioning pancreatic islet cell adenomas; a review of the literature and presentation of two new differential tests.

Authors:  E L CRAIN; G W THORN
Journal:  Medicine (Baltimore)       Date:  1949-12       Impact factor: 1.889

2.  MEN1 gene mutation analysis of sporadic adrenocortical lesions.

Authors:  B Görtz; J Roth; E J Speel; A Krähenmann; R R De Krijger; X Matias-Guiu; S Muletta-Feurer; K Rütmann; P Saremaslani; P U Heitz; P Komminoth
Journal:  Int J Cancer       Date:  1999-01-29       Impact factor: 7.396

3.  Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms.

Authors:  B Görtz; J Roth; A Krähenmann; R R de Krijger; S Muletta-Feurer; K Rütimann; P Saremaslani; E J Speel; P U Heitz; P Komminoth
Journal:  Am J Pathol       Date:  1999-02       Impact factor: 4.307

Review 4.  Glucagonomas and insulinomas.

Authors:  G Boden
Journal:  Gastroenterol Clin North Am       Date:  1989-12       Impact factor: 3.806

5.  Loss of heterozygosity on chromosome 11 in sporadic gastrinomas.

Authors:  M P Sawicki; Y J Wan; C L Johnson; J Berenson; R Gatti; E Passaro
Journal:  Hum Genet       Date:  1992-06       Impact factor: 4.132

6.  Insulinoma: diagnosis, surgical management and long-term follow-up. Review of 41 cases.

Authors:  D L Galbut; A M Markowitz
Journal:  Am J Surg       Date:  1980-05       Impact factor: 2.565

7.  The origin of gut and pancreatic neuroendocrine (APUD) cells--the last word?

Authors:  A Andrew; B Kramer; B B Rawdon
Journal:  J Pathol       Date:  1998-10       Impact factor: 7.996

8.  Functional and morphologic characterization of human insulinomas.

Authors:  M Berger; C Bordi; H J Cüppers; P Berchtold; F A Gries; H Münterfering; R Sailer; H Zimmermann; L Orci
Journal:  Diabetes       Date:  1983-10       Impact factor: 9.461

9.  Distribution patterns of proinsulin and insulin in human insulinomas: an immunohistochemical analysis in 76 tumors.

Authors:  J Roth; G Klöppel; O D Madsen; M J Storch; P U Heitz
Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol       Date:  1992

Review 10.  Clinical review 72: diagnosis and management of functioning islet cell tumors.

Authors:  R R Perry; A I Vinik
Journal:  J Clin Endocrinol Metab       Date:  1995-08       Impact factor: 5.958
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  6 in total

1.  Histologic and Molecular Profile of Pediatric Insulinomas: Evidence of a Paternal Parent-of-Origin Effect.

Authors:  Tricia R Bhatti; Karthik Ganapathy; Alison R Huppmann; Laura Conlin; Kara E Boodhansingh; Courtney MacMullen; Susan Becker; Linda M Ernst; N Scott Adzick; Eduardo D Ruchelli; Arupa Ganguly; Charles A Stanley
Journal:  J Clin Endocrinol Metab       Date:  2016-01-12       Impact factor: 5.958

2.  Putative tumor suppressor loci at 6q22 and 6q23-q24 are involved in the malignant progression of sporadic endocrine pancreatic tumors.

Authors:  A Barghorn; E J Speel; B Farspour; P Saremaslani; S Schmid; A Perren; J Roth; P U Heitz; P Komminoth
Journal:  Am J Pathol       Date:  2001-06       Impact factor: 4.307

3.  Co-existence of glucagonoma with recurrent insulinoma in a patient with multiple endocrine neoplasia-type 1 (MEN-1).

Authors:  Takamasa Nishiuchi; Hitomi Imachi; Koji Murao; Mako Fujiwara; Tomie Muraoka; Fumi Kikuchi; Yukiko Nishiuchi; Yoshio Kushida; Reiji Haba; Toshihiko Ishida
Journal:  Endocrine       Date:  2009-04-07       Impact factor: 3.633

4.  Amyloid-Rich Pancreatic Neuroendocrine Tumors: a Potential Diagnostic Pitfall in Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology (EUS-FNAC).

Authors:  Alessandro Gambella; Enrico Costantino Falco; Jasna Metovic; Francesca Maletta; Claudio De Angelis; Roberta Maragliano; Silvia Uccella; Donatella Pacchioni; Mauro Papotti
Journal:  Endocr Pathol       Date:  2021-06       Impact factor: 3.943

5.  Hypoglycemia secondary to insulinoma masking the onset of type 1 diabetes in an adolescent.

Authors:  Sriya Subramani; Andrew M Bellizzi; Nicholas Borcherding; Simon C Kao; Joseph Dillon; James Howe; Andrew W Norris; Michael J Tansey; Catherina T Pinnaro
Journal:  Clin Case Rep       Date:  2021-09-24

6.  The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels.

Authors:  Petra Dzianová; Seiya Asai; Martina Chrudinová; Lucie Kosinová; Pavlo Potalitsyn; Pavel Šácha; Romana Hadravová; Irena Selicharová; Jan Kříž; Johan P Turkenburg; Andrzej Marek Brzozowski; Jiří Jiráček; Lenka Žáková
Journal:  Open Biol       Date:  2020-10-21       Impact factor: 6.411
  6 in total

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