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Literature DB >> 12114400

Apoptosis: target of cancer therapy.

Carlos G Ferreira¹, Mirjam Epping, Frank A E Kruyt, Giuseppe Giaccone.

Abstract

Recent knowledge on apoptosis has made it possible to devise novel approaches, which exploit this process to treat cancer. In this review, we discuss in detail approaches to induce tumor cell apoptosis, their mechanism of action, stage of development, and possible drawbacks. Finally, the obstacles yet to be overcome and the perspectives for potential clinical use of apoptosis-triggering approaches in cancer therapy in the future are assessed.

Entities: Disease

Mesh：

Year: 2002 PMID： 12114400

Source DB: PubMed Journal: Clin Cancer Res ISSN： 1078-0432 Impact factor: 12.531

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Cited

65 in total

Review 1. Lung cancer therapeutics that target signaling pathways: an update.

Authors: M Roshni Ray; David Jablons; Biao He
Journal: Expert Rev Respir Med Date: 2010-10 Impact factor: 3.772

2. Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer.

Authors: Chandan Rana; Honit Piplani; Vivek Vaish; Bimla Nehru; S N Sanyal
Journal: Mol Cell Biochem Date: 2015-02-03 Impact factor: 3.396

3. Dracorhodin perchlorate induces G₁/G₀ phase arrest and mitochondria-mediated apoptosis in SK-MES-1 human lung squamous carcinoma cells.

Authors: Guangxin Zhang; Mei Sun; Yifan Zhang; Peiyan Hua; Xin Li; Ranji Cui; Xingyi Zhang
Journal: Oncol Lett Date: 2015-05-14 Impact factor: 2.967

4. Potentiation of tumor radiotherapy by a radiation-inducible oncolytic and oncoapoptotic adenovirus in cervical cancer xenografts.

Authors: Haibo Wang; Xin Song; He Zhang; Jianjun Zhang; Xiaodi Shen; Yixiong Zhou; Xianqun Fan; Liyan Dai; Guanxiang Qian; Andrew R Hoffman; Ji-Fan Hu; Shengfang Ge
Journal: Int J Cancer Date: 2011-05-30 Impact factor: 7.396

5. Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells.

Authors: Jia-Xuan Qiu; Zhi-Wei Zhou; Zhi-Xu He; Ruan Jin Zhao; Xueji Zhang; Lun Yang; Shu-Feng Zhou; Zong-Fu Mao
Journal: Drug Des Devel Ther Date: 2015-01-07 Impact factor: 4.162

Apoptosis: target of cancer therapy.

Review 1. Lung cancer therapeutics that target signaling pathways: an update.

2. Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer.

3. Dracorhodin perchlorate induces G₁/G₀ phase arrest and mitochondria-mediated apoptosis in SK-MES-1 human lung squamous carcinoma cells.

4. Potentiation of tumor radiotherapy by a radiation-inducible oncolytic and oncoapoptotic adenovirus in cervical cancer xenografts.

5. Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells.

6. The role of Ca2+ on the DADS-induced apoptosis in mouse-rat hybrid retina ganglion cells (N18).

7. Tumor-specific apoptotic gene targeting overcomes radiation resistance in esophageal adenocarcinoma.

8. Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas.

Review 9. Anaplastic thyroid cancer: molecular pathogenesis and emerging therapies.

10. Vitamin E analogues as inducers of apoptosis: structure-function relation.