C P Somanath1, S Jain, Y C Janardhan Reddy. 1. Department of Psychiatry, National Institute of Mental Health and NeuroSciences, Bangalore 560 029, India.
Abstract
BACKGROUND: Relatives of early-onset bipolar probands have greater risk for affective disorders than those of adult-onset bipolar probands. METHODS: Relatives of 50 adolescent bipolar I probands and 36 adult-onset bipolar probands (onset > or = 25 years) were assessed using the Family Interview for Genetic Studies (FIGS) by a qualified psychiatrist blind to the proband status. Morbid risk was calculated using Weinberg's method of age correction. RESULTS: Relatives of early-onset probands had significantly greater risk for affective disorders compared to the relatives of adult-onset bipolar probands. CONCLUSIONS: Early-onset bipolar disorder is more familial than the adult bipolar disorder. IMPLICATIONS: Subdivision of bipolar disorder according to age-at-onset may identify homogeneous subtypes useful for genetic studies. LIMITATIONS: Patients were recruited from a major psychiatric hospital. The family history method was used to collect information about relatives.
BACKGROUND: Relatives of early-onset bipolar probands have greater risk for affective disorders than those of adult-onset bipolar probands. METHODS: Relatives of 50 adolescent bipolar I probands and 36 adult-onset bipolar probands (onset > or = 25 years) were assessed using the Family Interview for Genetic Studies (FIGS) by a qualified psychiatrist blind to the proband status. Morbid risk was calculated using Weinberg's method of age correction. RESULTS: Relatives of early-onset probands had significantly greater risk for affective disorders compared to the relatives of adult-onset bipolar probands. CONCLUSIONS: Early-onset bipolar disorder is more familial than the adult bipolar disorder. IMPLICATIONS: Subdivision of bipolar disorder according to age-at-onset may identify homogeneous subtypes useful for genetic studies. LIMITATIONS: Patients were recruited from a major psychiatric hospital. The family history method was used to collect information about relatives.
Authors: Caleb M Pardue; Nicholas J Sibrava; Christina L Boisseau; Maria C Mancebo; Jane L Eisen; Steven A Rasmussen Journal: J Obsessive Compuls Relat Disord Date: 2014-07-01 Impact factor: 1.677
Authors: Euijung Ryu; Malik Nassan; Gregory D Jenkins; Sebastian M Armasu; Ana Andreazza; Susan L McElroy; Marquis P Vawter; Mark A Frye; Joanna M Biernacka Journal: Mol Neuropsychiatry Date: 2017-10-28