Literature DB >> 12113826

Novel cyclourethane-derived HIV protease inhibitors: a ring-closing olefin metathesis based strategy.

Arun K Ghosh1, Lisa M Swanson, Chunfeng Liu, Khaja Azhar Hussain, Hanna Cho, D Eric Walters, Louis Holland, Jim Buthod.   

Abstract

A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against HIV-1 protease.

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Year:  2002        PMID： 12113826     DOI： 10.1016/s0960-894x(02)00300-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands.

Authors:  Arun K Ghosh; W Sean Fyvie; Margherita Brindisi; Melinda Steffey; Johnson Agniswamy; Yuan-Fang Wang; Manabu Aoki; Masayuki Amano; Irene T Weber; Hiroaki Mitsuya
Journal:  Bioorg Med Chem Lett       Date:  2017-09-06       Impact factor: 2.823

2.  Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands.

Authors:  Arun K Ghosh; Gary E Schiltz; Linah N Rusere; Heather L Osswald; D Eric Walters; Masayuki Amano; Hiroaki Mitsuya
Journal:  Org Biomol Chem       Date:  2014-09-21       Impact factor: 3.876
  2 in total

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