| Literature DB >> 12113823 |
Daniele Passarella1, Alessandra Consonni, Alessandra Giardini, Giordano Lesma, Alessandra Silvani.
Abstract
Synthesis of Delta(7,8)-morphinan-6-one by Grewe cyclization and bromoketalization reaction as crucial steps is described. Introduction of a hydroxyl group at 14-position is demonstrated by direct oxidation with MnO(2) in the presence of silica gel.Entities:
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Year: 2002 PMID： 12113823 DOI： 10.1016/s0960-894x(02)00280-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823