| Literature DB >> 12113812 |
Ahmed Kamal1, B S Narayan Reddy, G Suresh Kumar Reddy, G Ramesh.
Abstract
The facile synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrid analogues is described. The compounds are prepared with varying degrees of linker length in order to probe the structural requirements for optimal in vitro anti-tumour activity. Some of these new hybrid compounds showed higher cytotoxic activity than the existing natural and synthetic pyrrolo[2,1-c][1,4]benzodiazepines.Entities:
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Year: 2002 PMID： 12113812 DOI： 10.1016/s0960-894x(02)00326-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823