Literature DB >> 12113807

Photo-oxygenation of geraniol: synthesis of a novel series of hydroxy-functionalized anti-malarial 1,2,4-trioxanes.

Chandan Singh1, Nitin Gupta, Sunil K Puri.   

Abstract

Photo-oxygenation of geraniol 2, an abundantly available allylic alcohol, furnished a mixture of mono- and di-hydroperoxy products; the latter have been used for the preparation of a novel series of hydroxy-functionalized anti-malarial 1,2,4-trioxanes (7a-d, 8a-d).

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Year:  2002        PMID: 12113807     DOI: 10.1016/s0960-894x(02)00320-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity.

Authors:  Dionissia A Pepe; Dimitra Toumpa; Christiane André-Barrès; Christophe Menendez; Elisabeth Mouray; Michel Baltas; Philippe Grellier; Dionissios Papaioannou; Constantinos M Athanassopoulos
Journal:  ACS Med Chem Lett       Date:  2020-03-24       Impact factor: 4.345

Review 2.  Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.

Authors:  Alexander O Terent'ev; Dmitry A Borisov; Vera A Vil'; Valery M Dembitsky
Journal:  Beilstein J Org Chem       Date:  2014-01-08       Impact factor: 2.883

3.  Isoprenoid Alcohols are Susceptible to Oxidation with Singlet Oxygen and Hydroxyl Radicals.

Authors:  Joanna Komaszylo Née Siedlecka; Magdalena Kania; Marek Masnyk; Piotr Cmoch; Iwona Lozinska; Zbigniew Czarnocki; Karolina Skorupinska-Tudek; Witold Danikiewicz; Ewa Swiezewska
Journal:  Lipids       Date:  2015-12-30       Impact factor: 1.880

4.  Single Ascending Dose Safety and Pharmacokinetics of CDRI-97/78: First-in-Human Study of a Novel Antimalarial Drug.

Authors:  N Shafiq; S Rajagopalan; H N Kushwaha; N Mittal; N Chandurkar; A Bhalla; S Kaur; P Pandhi; G D Puri; S Achuthan; A Pareek; S K Singh; J S Srivastava; S P S Gaur; S Malhotra
Journal:  Malar Res Treat       Date:  2014-03-27
  4 in total

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