| Literature DB >> 12113799 |
David Weinshenker1, Patricia Szot.
Abstract
The catecholamines norepinephrine and dopamine are abundant in the CNS, and modulate neuronal excitability via G-protein-coupled receptor signaling. This review covers the history of research concerning the role of catecholamines in modulating seizure susceptibility in animal models of epilepsy. Traditionally, most work on this topic has been anatomical, pharmacological, or physiological in nature. However, the recent advances in transgenic and knockout mouse technology provide new tools to study catecholamines and their roles in seizure susceptibility. New results from genetically engineered mice with altered catecholamine signaling, as well as possibilities for future experiments, are discussed. Copyright 2002 Elsevier Science Inc.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12113799 DOI： 10.1016/s0163-7258(02)00218-8
Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310