Gram-scale synthesis of (+)- and (-)-trans-10-amino-9-hydroxy-9,10-dihydrophenanthrene by enzymatic hydrolysis.

The enzymatic resolution of (+/-)-trans-10-azido-9-acetoxy-9,10-dihydrophenanthrene by Candida cylindracea lipase-catalyzed hydrolysis was achieved on the gram-scale with excellent yield and enantiomeric excess. The resulting (+)- and (-)-amino alcohols were derivatized to alpha-hydroxy-N-benzenesulphonamides. Copyright 2002 Wiley-Liss, Inc.