| Literature DB >> 12110320 |
Sachiko Tsukamoto1, Kyoko Tomise, Keiko Miyakawa, Bae-Cheon Cha, Takamasa Abe, Toshiyuki Hamada, Hiroshi Hirota, Tomihisa Ohta.
Abstract
Two new bisalkaloids, dipiperamides D and E, were isolated as inhibitors of a drug metabolizing enzyme cytochrome P450 (CYP) 3A4 from the white pepper, Piper nigrum. Their structures were elucidated by spectroscopic methods. Dipiperamides D and E showed potent CYP3A4 inhibition with IC(50) values of 0.79 and 0.12 microM, respectively, and other metabolites from the pepper were moderately active or inactive.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12110320 DOI： 10.1016/s0968-0896(02)00130-x
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641