| Literature DB >> 12110313 |
Vijay K Agrawal1, Rashmi Sohgaura, Padmakar V Khadikar.
Abstract
Quantitative structure-activity relationship (QSAR) studies for 2,6-substituted 2,4-diaminopyrido[3,2-d] pyrimidine analogues of piritrexim (PTX) as inhibitors of dihydrofolate reductase (DHFR) are now made using topological indices. The results have shown that best models are obtained by multiparametric analysis. The predictive potential of the model is discussed on the basis of a cross-validation method.Entities:
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Year: 2002 PMID： 12110313 DOI： 10.1016/s0968-0896(02)00159-1
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641