Literature DB >> 12110309

Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities.

Hatice N Dogan1, Arzu Duran, Sevim Rollas, Göksel Sener, Meral K Uysal, Dumrul Gülen.   

Abstract

Two new series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized for their possible anticonvulsant, antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100mg/kg i.p. against pentylenetetrazole-induced convulsions in mice ranged from 0 to 90%. Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin.

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Year:  2002        PMID： 12110309     DOI： 10.1016/s0968-0896(02)00143-8

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  11 in total

1.  A convenient four-component one-pot synthesis of 2-amino-1,3,4-thiadiazoles in water.

Authors:  Peng Liu; Ao-Ze Su; Yuan-Qiang Wang; Ze-Mei Ge; Tie-Ming Cheng; Run-Tao Li
Journal:  Mol Divers       Date:  2014-06-29       Impact factor: 2.943

2.  NMK-TD-100, a novel microtubule modulating agent, blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin.

Authors:  Surela Bhattacharya; N Maruthi Kumar; Arnab Ganguli; Mukund P Tantak; Dalip Kumar; Gopal Chakrabarti
Journal:  PLoS One       Date:  2013-10-07       Impact factor: 3.240

3.  5-[(2-Methyl-4-nitro-1H-imidazol-1-yl)meth-yl]-1,3,4-thia-diazol-2-amine.

Authors:  M K Usha; S Madan Kumar; H S Vidyashree Jois; B Kalluraya; N K Lokanath; D Revannasiddaiah
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-11-27

Review 4.  Synthetic methods, chemistry, and the anticonvulsant activity of thiadiazoles.

Authors:  Bhawna Sharma; Amita Verma; Sunil Prajapati; Upendra Kumar Sharma
Journal:  Int J Med Chem       Date:  2013-04-30

5.  Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid-base interactions.

Authors:  Agnieszka Kudelko; Karolina Jasiak; Krzysztof Ejsmont
Journal:  Monatsh Chem       Date:  2014-12-20       Impact factor: 1.451

Review 6.  2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents.

Authors:  Georgeta Serban; Oana Stanasel; Sanda Bota; Eugenia Serban
Journal:  Drug Des Devel Ther       Date:  2018-05-31       Impact factor: 4.162

7.  New Route Synthesis of Thiadiazoles, Bisthiadiazoles, Thiadiazolotriazines, and Pyrazolothiadiazoles Based on Hydrazonoyl Halides and Dihydrazinylthiadiazole.

Authors:  Abdelwahed R Sayed; Shar Saad Al-Shihry
Journal:  Molecules       Date:  2017-02-21       Impact factor: 4.411

8.  Synthesis of new 1,3,4-thiadiazole and 1,2,3,4-oxathiadiazole derivatives from carbohydrate precursors and study of their effect on tyrosinase enzyme.

Authors:  Mohamed M El-Sadek; Seham Y Hassan; Huda E Abdelwahab; Galila A Yacout
Journal:  Molecules       Date:  2012-07-11       Impact factor: 4.411

9.  Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives.

Authors:  Lukasz Popiołek; Urszula Kosikowska; Liliana Mazur; Maria Dobosz; Anna Malm
Journal:  Med Chem Res       Date:  2012-11-11       Impact factor: 1.965

10.  Synthesis and fungicidal activity of novel 2,5-disubstituted-1,3,4- thiadiazole derivatives containing 5-phenyl-2-furan.

Authors:  Zi-Ning Cui; Ya-Sheng Li; De-Kun Hu; Hao Tian; Jia-Zhen Jiang; Yuan Wang; Xiao-Jing Yan
Journal:  Sci Rep       Date:  2016-01-29       Impact factor: 4.379
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