| Literature DB >> 12110050 |
N A Rodriguez1, K D Garcia, J D Fortman, T A Hewett, R M Bunte, B T Bennett.
Abstract
In recent years, the emphasis on aging research, has led to an increase in the number of aged macaques being maintained in some research facilities with a subsequent increase in the occurrence of age-related diseases. One of the most commonly reported age related diseases is intestinal adenocarcinoma. At the University of Illinois at Chicago (UIC), which maintains a colony of approximately 55 aged rhesus macaques 13 cases of intestinal adenocarcinoma were diagnosed within a 25-month period. This report provides a comprehensive description of the clinical findings for intestinal adenocarcinoma in aged rhesus macaques, including results from physical examinations, laboratory tests, radiographic evaluations, gross and histopathologic findings as well as a comparison with the disease condition in humans. The use of carcinoembryonic antigen as a potential tumor marker was evaluated by immunohistochemical analysis of tissue specimens in 10 cases. Intestinal adenocarcinoma is a disease condition that should be of concern to individuals responsible for the care of aged rhesus macaques.Entities:
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Year: 2002 PMID： 12110050 DOI： 10.1034/j.1600-0684.2002.01001.x
Source DB: PubMed Journal: J Med Primatol ISSN： 0047-2565 Impact factor: 0.667