Literature DB >> 12109666

Hepatitis C virus and its roles in cell proliferation.

Kunitada Shimotohno1, Koichi Watashi, Katsuya Tsuchihara, Katsuhiko Fukuda, Hiroyuki Marusawa, Makoto Hijikata.   

Abstract

Hepatitis C virus (HCV) causes chronic hepatitis and is linked to the development of hepatocellular carcinoma (HCC). The role of HCV infection in the development of HCC remains to be clarified. We analyzed the effect of HCV core protein on modulation of cell proliferation. HCV core protein was shown to have at least two functions: activation of the Ras/Raf signaling pathway and anti-apototic function.

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Year:  2002        PMID： 12109666     DOI： 10.1007/bf02990100

Source DB:  PubMed          Journal:  J Gastroenterol        ISSN： 0944-1174            Impact factor:   7.527


  22 in total

1.  Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis.

Authors:  N Zhu; A Khoshnan; R Schneider; M Matsumoto; G Dennert; C Ware; M M Lai
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

Review 2.  Molecular virology of hepatitis C virus.

Authors:  B Clarke
Journal:  J Gen Virol       Date:  1997-10       Impact factor: 3.891

3.  Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein.

Authors:  R B Ray; K Meyer; R Steele; A Shrivastava; B B Aggarwal; R Ray
Journal:  J Biol Chem       Date:  1998-01-23       Impact factor: 5.157

4.  Regulated processing of hepatitis C virus core protein is linked to subcellular localization.

Authors:  Q Liu; C Tackney; R A Bhat; A M Prince; P Zhang
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

5.  Transcriptional repression of p53 promoter by hepatitis C virus core protein.

Authors:  R B Ray; R Steele; K Meyer; R Ray
Journal:  J Biol Chem       Date:  1997-04-25       Impact factor: 5.157

6.  Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene.

Authors:  J Chang; S H Yang; Y G Cho; S B Hwang; Y S Hahn; Y C Sung
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

7.  Biosynthesis and biochemical properties of the hepatitis C virus core protein.

Authors:  E Santolini; G Migliaccio; N La Monica
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

8.  Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein.

Authors:  R B Ray; L M Lagging; K Meyer; R Steele; R Ray
Journal:  Virus Res       Date:  1995-08       Impact factor: 3.303

9.  Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors.

Authors:  A Shrivastava; S K Manna; R Ray; B B Aggarwal
Journal:  J Virol       Date:  1998-12       Impact factor: 5.103

10.  Tumourigenicity of MTG8, a leukaemia-related gene, in concert with v-Ha-ras gene in BALB/3T3 cells.

Authors:  E Sueoka; N Sueoka; S Okabe; A Komori; M Suganuma; T Kozu; H Fujiki
Journal:  Br J Haematol       Date:  1998-06       Impact factor: 6.998
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  3 in total

Review 1.  Sorafenib for treatment of hepatocellular carcinoma: a systematic review.

Authors:  Bingru Xie; David H Wang; Stuart Jon Spechler
Journal:  Dig Dis Sci       Date:  2012-03-27       Impact factor: 3.199

2.  Chronic hepatitis C.

Authors:  Jae Young Jang; Raymond T Chung
Journal:  Gut Liver       Date:  2011-06-24       Impact factor: 4.519

3.  The molecular pathogenesis and clinical implications of hepatocellular carcinoma.

Authors:  Makoto Meguro; Toru Mizuguchi; Masaki Kawamoto; Koichi Hirata
Journal:  Int J Hepatol       Date:  2011-12-04
  3 in total

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