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Literature DB >> 12109665

Helicobacter pylori infection and molecular changes in gastric carcinogenesis.

Matthias P A Ebert¹, Laszlo Schandl, Peter Malfertheiner.

Abstract

In recent years there has been much progress in understanding the pathogenesis of gastric cancer. The role of individual factors in gastric carcinogenesis continues to be debated and is also subject to further analysis. In addition to the activation of oncogenes and the inactivation of tumor suppressor genes, alteration of adhesion molecules seems to be critical for the development of gastric cancer. Helicobacter pylori has been linked to an increased risk of developing gastric cancer, and the molecular changes induced by H. pylori are currently being investigated. Recent studies indicate that H. pylori induces cell proliferation and apoptosis during the early phase of chronic inflammation of the gastric mucosa, whereas in the malignant transformation of the gastric mucosa apoptosis is inhibited and adhesion of gastric epithelial cells is impaired. This review focuses on the role of H. pylori in the development of molecular changes in gastric cancer and its preneoplastic lesions.

Entities: Disease Species

Mesh：

Year: 2002 PMID： 12109665 DOI： 10.1007/bf02990099

Source DB: PubMed Journal: J Gastroenterol ISSN： 0944-1174 Impact factor: 7.527

35 in total

Review 1. The importance of the E-cadherin-catenin complex in the maintenance of intestinal epithelial homoeostasis: more than intercellular glue?

Authors: A Jawhari; M Farthing; M Pignatelli
Journal: Gut Date: 1997-11 Impact factor: 23.059

2. Amplification, overexpression, and rearrangement of the erbB-2 protooncogene in primary human stomach carcinomas.

Authors: J B Park; J S Rhim; S C Park; S W Kimm; M H Kraus
Journal: Cancer Res Date: 1989-12-01 Impact factor: 12.701

3. Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: relationship with patient survival.

Authors: A Jawhari; S Jordan; S Poole; P Browne; M Pignatelli; M J Farthing
Journal: Gastroenterology Date: 1997-01 Impact factor: 22.682

4. Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer.

Authors: W S Park; R R Oh; J Y Park; S H Lee; M S Shin; Y S Kim; S Y Kim; H K Lee; P J Kim; S T Oh; N J Yoo; J Y Lee
Journal: Cancer Res Date: 1999-09-01 Impact factor: 12.701

5. alpha-catenin expression is decreased in human gastric cancers and in the gastric mucosa of first degree relatives.

Authors: J Yu; M P Ebert; S Miehlke; H Rost; U Lendeckel; A Leodolter; M Stolte; E Bayerdörffer; P Malfertheiner
Journal: Gut Date: 2000-05 Impact factor: 23.059

6. Helicobacter pylori infection induces gastric cancer in mongolian gerbils.

Authors: T Watanabe; M Tada; H Nagai; S Sasaki; M Nakao
Journal: Gastroenterology Date: 1998-09 Impact factor: 22.682

7. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

Authors: K F Becker; M J Atkinson; U Reich; I Becker; H Nekarda; J R Siewert; H Höfler
Journal: Cancer Res Date: 1994-07-15 Impact factor: 12.701

8. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii.

Authors: A Nomura; G N Stemmermann; P H Chyou; I Kato; G I Perez-Perez; M J Blaser
Journal: N Engl J Med Date: 1991-10-17 Impact factor: 91.245

9. p53 gene mutations and protein nuclear accumulation are early events in intestinal type gastric cancer but late events in diffuse type.

Authors: G N Ranzani; O Luinetti; L S Padovan; D Calistri; B Renault; M Burrel; D Amadori; R Fiocca; E Solcia
Journal: Cancer Epidemiol Biomarkers Prev Date: 1995 Apr-May Impact factor: 4.254

Helicobacter pylori infection and molecular changes in gastric carcinogenesis.

Review 1. The importance of the E-cadherin-catenin complex in the maintenance of intestinal epithelial homoeostasis: more than intercellular glue?

2. Amplification, overexpression, and rearrangement of the erbB-2 protooncogene in primary human stomach carcinomas.

3. Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: relationship with patient survival.

4. Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer.

5. alpha-catenin expression is decreased in human gastric cancers and in the gastric mucosa of first degree relatives.

6. Helicobacter pylori infection induces gastric cancer in mongolian gerbils.

7. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

8. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii.

9. p53 gene mutations and protein nuclear accumulation are early events in intestinal type gastric cancer but late events in diffuse type.

10. Helicobacter pylori increases proliferation of gastric epithelial cells.

1. DLAT subunit of the pyruvate dehydrogenase complex is upregulated in gastric cancer-implications in cancer therapy.

2. Therapeutic actions of melatonin on gastrointestinal cancer development and progression.

3. Investigation of Helicobacter pylori colonization in laryngeal neoplasia.

4. Old and new TNM in carcinoma of the gastric antrum: analysis of our personal experience.

5. Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review).