Literature DB >> 12109112

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.

Marie E Migaud1, Rupert C Wilmouth, Gary I Mills, Gareth J Wayne, Catherine Risley, Christopher Chambers, Simon J F Macdonald, Christopher J Schofield.   

Abstract

Novel 5,5-fused thiophene lactams are potent inhibitors and acylating agents of HNE and PPE.

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Year:  2002        PMID： 12109112     DOI： 10.1039/b111627d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation.

Authors:  Christopher T Lohans; Emma van Groesen; Kiran Kumar; Catherine L Tooke; James Spencer; Robert S Paton; Jürgen Brem; Christopher J Schofield
Journal:  Angew Chem Int Ed Engl       Date:  2018-01-05       Impact factor: 15.336

2.  Investigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibition.

Authors:  Hwanho Choi; Robert S Paton; Hwangseo Park; Christopher J Schofield
Journal:  Org Biomol Chem       Date:  2016-04-26       Impact factor: 3.876
  2 in total

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