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Literature DB >> 12108616

Efficacy of porcine secretin in children with autism and pervasive developmental disorder.

Janet K Kern¹, S Van Miller, Patricia A Evans, Madhukar H Trivedi.

Abstract

Secretin, a gastrointestinal (GI) hormone, was reported in a preliminary study to improve language and behavior in children with autism/pervasive developmental disorder (PDD) and chronic diarrhea. To determine the efficacy of secretin, we completed a double-blind, placebo-controlled, crossover (3 weeks) study in children with autism/PDD and various GI conditions using a single dose of intravenous porcine secretin. Children with chronic, active diarrhea showed a reduction in aberrant behaviors when treated with the secretin but not when treated with the placebo. Children with no GI problems are unaffected by either secretin or placebo. The improvement seen with secretin in children with autism/PDD and chronic diarrhea suggests that there may be a subtype of children with autism/PDD who respond to secretin.

Entities: Disease Gene Species

Mesh：

Substances：
Secretin

Year: 2002 PMID： 12108616 DOI： 10.1023/a:1015441428154

Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257

21 in total

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12 in total

1. In children with autism, is intravenous secretin more effective than placebo in improving social skills, communication, behaviour or global functioning?: Part A: Evidence-based answer and summary.

Authors: Susan Petryk
Journal: Paediatr Child Health Date: 2004-04 Impact factor: 2.253

2. Global hormone profiling of murine placenta reveals Secretin expression.

Authors: K Knox; D Leuenberger; A A Penn; J C Baker
Journal: Placenta Date: 2011-09-25 Impact factor: 3.481

3. Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior.

Authors: Ichiko Nishijima; Takanori Yamagata; Corinne M Spencer; Edwin J Weeber; Olga Alekseyenko; J David Sweatt; Mariko Y Momoi; Masayuki Ito; Dawna L Armstrong; David L Nelson; Richard Paylor; Allan Bradley
Journal: Hum Mol Genet Date: 2006-09-28 Impact factor: 6.150

Efficacy of porcine secretin in children with autism and pervasive developmental disorder.

1. Improved social and language skills after secretin administration in patients with autistic spectrum disorders.

2. Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder.

3. A Double-Blind, Placebo-Controlled Trial of Secretin for the Treatment of Autistic Disorder.

4. Abnormal intestinal permeability in children with autism.

5. Sulfate and oxalate exchange for bicarbonate across the basolateral membrane of rabbit ileum.

6. First report of a Canadian epidemiological study of autistic syndromes.

7. The prevalence of autism in Nagoya, Japan: a total population study.

8. Disruption of sulphated glycosaminoglycans in intestinal inflammation.

9. [Celiac disease in adults revealed by sensory-motor neuropathy].

10. Does cryptic gluten sensitivity play a part in neurological illness?

1. In children with autism, is intravenous secretin more effective than placebo in improving social skills, communication, behaviour or global functioning?: Part A: Evidence-based answer and summary.

2. Global hormone profiling of murine placenta reveals Secretin expression.

3. Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior.

Review 4. Gastrointestinal factors in autistic disorder: a critical review.

Review 5. Intravenous secretin for autism spectrum disorders (ASD).

Review 6. Secretin as a treatment for autism: a review of the evidence.

7. Insights into synaptic function from mouse models of human cognitive disorders.

8. Secretin: hypothalamic distribution and hypothesized neuroregulatory role in autism.

9. Short report: Autistic gastrointestinal and eating symptoms treated with secretin: a subtype of autism.

Review 10. Thimerosal exposure and the role of sulfation chemistry and thiol availability in autism.