BACKGROUND: This is an epidemiological study of a possible causal role of marijuana use in the development of Major Depressive Episode (MDE). Male-female differences in the suspected causal association have also been studied. METHOD: Data are from 6,792 National Comorbidity Survey participants aged 15-45 years, assessed via the University of Michigan modified version of the Composite International Diagnostic Interview (UM-CIDI). Survival analysis methods were used to estimate cumulative risk of MDE by levels of marijuana use and to estimate suspected causal associations after adjustment for other influences. RESULTS: The risk of first MDE was moderately associated with the number of occasions of marijuana use and with more advanced stages of marijuana use. Relative to never users, non-dependent marijuana users had 1.6 times greater risk of MDE (95 % Confidence Interval: 1.1, 2.2), even with statistical adjustment for sex, birth cohorts, alcohol dependence, and history of daily tobacco smoking. CONCLUSIONS: There was male-female variation in the degree of association between stage of marijuana involvement and MDE, but the strength of the association is modest at best.
BACKGROUND: This is an epidemiological study of a possible causal role of marijuana use in the development of Major Depressive Episode (MDE). Male-female differences in the suspected causal association have also been studied. METHOD: Data are from 6,792 National Comorbidity Survey participants aged 15-45 years, assessed via the University of Michigan modified version of the Composite International Diagnostic Interview (UM-CIDI). Survival analysis methods were used to estimate cumulative risk of MDE by levels of marijuana use and to estimate suspected causal associations after adjustment for other influences. RESULTS: The risk of first MDE was moderately associated with the number of occasions of marijuana use and with more advanced stages of marijuana use. Relative to never users, non-dependent marijuana users had 1.6 times greater risk of MDE (95 % Confidence Interval: 1.1, 2.2), even with statistical adjustment for sex, birth cohorts, alcohol dependence, and history of daily tobacco smoking. CONCLUSIONS: There was male-female variation in the degree of association between stage of marijuana involvement and MDE, but the strength of the association is modest at best.
Authors: Ron de Graaf; Mirjana Radovanovic; Margriet van Laar; Brian Fairman; Louisa Degenhardt; Sergio Aguilar-Gaxiola; Ronny Bruffaerts; Giovanni de Girolamo; John Fayyad; Oye Gureje; Josep Maria Haro; Yueqin Huang; Stanislav Kostychenko; Jean-Pierre Lépine; Herbert Matschinger; Maria Elena Medina Mora; Yehuda Neumark; Johan Ormel; Jose Posada-Villa; Dan J Stein; Hisateru Tachimori; J Elisabeth Wells; James C Anthony Journal: Am J Epidemiol Date: 2010-06-09 Impact factor: 4.897
Authors: Rachel L Gunn; Angela K Stevens; Lauren Micalizzi; Kristina M Jackson; Brian Borsari; Jane Metrik Journal: Exp Clin Psychopharmacol Date: 2020-03-05 Impact factor: 3.157
Authors: Judith S Brook; Chenshu Zhang; Elizabeth Rubenstone; Brian A Primack; David W Brook Journal: Addict Behav Date: 2016-06-07 Impact factor: 3.913