High frequency oscillations in respiratory networks: functionally significant or phenomenological?

Inspiratory activities, whether recorded from medullary neurons, motoneurons or motor nerves, feature prominent oscillations in high (50-120 Hz) and medium (15-50 Hz) frequency ranges. These oscillations have been extensively characterized and are considered signatures of respiratory network activity. Their functional significance, however, if any, remains unknown. Here we review the literature describing the nature and origin of these oscillations as well as their modulation during development and by mechanoreceptive and chemoreceptive feedback, respiratory- and non-respiratory-related behaviors, temperature and anesthesia. We then consider the potential significance of these oscillations for respiratory network function by drawing on analyses of distributed motor and sensory networks of the cortex where current interest in oscillatory activity, and the synchronization of neural discharge that can result, is based on the increased efficacy with which synchronous inputs influence neuronal output, and the role that synchronous activity may play in information coding. We speculate that synchronized oscillations at the network level help coordinate activity in distributed rhythm and pattern generating systems and at the muscle level enhance force development. Data most strongly support that oscillatory synaptic inputs play an important role in controlling timing and pattern of action potential output.