BACKGROUND: We report the occurrence of fatal intracerebral hemorrhage associated with using a combination of antithrombotic agents, including abciximab, in patients undergoing neurointerventional procedures. SUMMARY OF REPORT: Seven patients (average age 60, range 46 to 73 years) developed fatal intracerebral hemorrhages associated with neurointerventional procedures and the use of intravenous abciximab. The procedures included angioplasty and stent placement in the cervical internal carotid artery (n=4), angioplasty of the intracranial internal carotid artery (n=1), and angioplasty of the middle cerebral artery (n=2). Clinical deterioration was observed within 1 hour of the procedure in 5 patients and 7 and 8 hours after the procedure, respectively, in the remaining 2 patients. All patients had received heparin and clopidogrel; 6 had also received aspirin. CONCLUSIONS: Intracerebral hemorrhages can occur after neurointerventional procedures in patients with recent cerebral ischemic events, particularly when aggressive antithrombotic treatment is used.
BACKGROUND: We report the occurrence of fatal intracerebral hemorrhage associated with using a combination of antithrombotic agents, including abciximab, in patients undergoing neurointerventional procedures. SUMMARY OF REPORT: Seven patients (average age 60, range 46 to 73 years) developed fatal intracerebral hemorrhages associated with neurointerventional procedures and the use of intravenous abciximab. The procedures included angioplasty and stent placement in the cervical internal carotid artery (n=4), angioplasty of the intracranial internal carotid artery (n=1), and angioplasty of the middle cerebral artery (n=2). Clinical deterioration was observed within 1 hour of the procedure in 5 patients and 7 and 8 hours after the procedure, respectively, in the remaining 2 patients. All patients had received heparin and clopidogrel; 6 had also received aspirin. CONCLUSIONS:Intracerebral hemorrhages can occur after neurointerventional procedures in patients with recent cerebral ischemic events, particularly when aggressive antithrombotic treatment is used.
Authors: V Puetz; G Gahn; U Becker; D Mucha; A Mueller; N U Weir; B Wiedemann; R von Kummer Journal: AJNR Am J Neuroradiol Date: 2007-11-07 Impact factor: 3.825
Authors: Jan Gralla; Adam T M Rennie; Rufus A Corkill; Shivendra T Lalloo; Andrew Molyneux; James V Byrne; Wilhem Kuker Journal: Neuroradiology Date: 2008-09-20 Impact factor: 2.804
Authors: Jacques Sedat; Yves Chau; Lydiane Mondot; Richard Chemla; Michel Lonjon; Bernard Padovani Journal: Neuroradiology Date: 2013-11-27 Impact factor: 2.804
Authors: K Imai; T Mori; H Izumoto; T Kunieda; N Takabatake; S Yamamoto; M Watanabe Journal: AJNR Am J Neuroradiol Date: 2008-01-17 Impact factor: 3.825