Literature DB >> 12104055

Osteonectin-expressing cells in human stomach cancer and their possible clinical significance.

Hack-Young Maeng1, Seok Bean Song, Dong-Kug Choi, Kyoon Eon Kim, Hyun Young Jeong, Yoshiyuki Sakaki, Chie Furihata.   

Abstract

The clinical significance of osteonectin in human stomach cancer was examined immunohistochemically and molecular biologically in 31 differentiated and eight undifferentiated stomach adenocarcinomas and 19 non-cancer stomach tissues. Osteonectin-mAb-stained cells were observed in stroma of 90% differentiated and 63% undifferentiated adenocarcinomas, and of 26% non-cancer stomach tissues. Competitive reverse transcriptase polymerase chain reaction results generally coincided with immunohistochemical data. The present results suggest that osteonectin is highly expressed in reactive stroma associated with invasive differentiated adenocarcinomas and that it may serve as a useful clinical diagnostic marker for stomach cancer.

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Year:  2002        PMID： 12104055     DOI： 10.1016/s0304-3835(02)00191-x

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  9 in total

1.  Clinical significance of secreted protein, acidic and cysteine-rich gene expression in patients with stage II/III gastric cancer following curative resection and adjuvant chemotherapy with S-1.

Authors:  Yoshihiro Suzuki; Takashi Oshima; Kazue Yoshihara; Kentaro Sakamaki; Toru Aoyama; Haruhiko Cho; Manabu Shiozawa; Takaki Yoshikawa; Yasushi Rino; Toshio Imada; Munetaka Masuda
Journal:  Oncol Lett       Date:  2018-03-13       Impact factor: 2.967

2.  Differential Expression of SPARC in Intestinal-type Gastric Cancer Correlates with Tumor Progression and Nodal Spread.

Authors:  Konrad Franke; Stacy Carl-McGrath; Friedrich-Wilhelm Röhl; Uwe Lendeckel; Matthias Pa Ebert; Marc Tänzer; Matthias Pross; Christoph Röcken
Journal:  Transl Oncol       Date:  2009-12       Impact factor: 4.243

3.  Downregulation of SPARC expression decreases gastric cancer cellular invasion and survival.

Authors:  Jie Yin; Guowei Chen; Yucun Liu; Si Liu; Pengyuan Wang; Yuanlian Wan; Xin Wang; Jing Zhu; Hongqiao Gao
Journal:  J Exp Clin Cancer Res       Date:  2010-06-02

4.  Overexpression of SPARC gene in human gastric carcinoma and its clinic-pathologic significance.

Authors:  C-S Wang; K-H Lin; S-L Chen; Y-F Chan; S Hsueh
Journal:  Br J Cancer       Date:  2004-11-29       Impact factor: 7.640

5.  High secreted protein acidic and rich in cysteine expression in peritumoral fibroblasts predicts better prognosis in patients with resectable gastric cancer.

Authors:  Masao Nakajima; Shigefumi Yoshino; Shinsuke Kanekiyo; Noriko Maeda; Kazuhiko Sakamoto; Ryoichi Tsunedomi; Nobuaki Suzuki; Shigeru Takeda; Shigeru Yamamoto; Shoichi Hazama; Yoshinobu Hoshii; Atsunori Oga; Hiroshi Itoh; Tomio Ueno; Hiroaki Nagano
Journal:  Oncol Lett       Date:  2017-11-15       Impact factor: 2.967

Review 6.  Stromal Protein-Mediated Immune Regulation in Digestive Cancers.

Authors:  Pia Gamradt; Christelle De La Fouchardière; Ana Hennino
Journal:  Cancers (Basel)       Date:  2021-01-05       Impact factor: 6.639

7.  SPARC: a matricellular regulator of tumorigenesis.

Authors:  Shanna A Arnold; Rolf A Brekken
Journal:  J Cell Commun Signal       Date:  2009-10-07       Impact factor: 5.782

8.  Appearance of osteonectin-expressing fibroblastic cells in early rat stomach carcinogenesis and stomach tumors induced with N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  Hack-Young Maeng; Dong-Kug Choi; Motoi Takeuchi; Masami Yamamoto; Michiyo Tominaga; Tetsuya Tsukamoto; Masae Tatematsu; Takashi Ito; Yoshiyuki Sakaki; Chie Furihata
Journal:  Jpn J Cancer Res       Date:  2002-09

9.  The relationship between stromal cell derived SPARC in human gastric cancer tissue and its clinicopathologic significance.

Authors:  Yi Gao; Shui-Ping Yin; Xu-Shi Xie; Dan-Dan Xu; Wei-Dong Du
Journal:  Oncotarget       Date:  2017-09-21
  9 in total

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