| Literature DB >> 12104041 |
Cheppail Ramachandran1, Hugo B Fonseca, Perseus Jhabvala, Enrique A Escalon, Steven J Melnick.
Abstract
The inhibitory effect of curcumin, the yellow-colored pigment from turmeric, on telomerase activity was analyzed in human mammary epithelial (MCF-10A) and breast cancer (MCF-7) cells. Telomerase activity in MCF-7 cells is 6.9-fold higher than that of human mammary epithelial cells. In MCF-7 cells, telomerase activity decreased with increasing concentrations of curcumin, inhibiting about 93.4% activity at 100 microM concentration. The inhibition of telomerase activity in MCF-7 cells may be due to down-regulation of hTERT expression. Increasing concentrations of curcumin caused a steady decrease in the level of hTERT mRNA in MCF-7 cells whereas the level of hTER and c-myc mRNAs remained the same. Our results suggest that curcumin inhibits telomerase activity by down-regulating hTERT expression in breast cancer cells and this down-regulation is not through the c-myc pathway.Entities:
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Year: 2002 PMID： 12104041 DOI： 10.1016/s0304-3835(02)00192-1
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679