Literature DB >> 12103440

Glial cell line-derived neurotrophic factor enhances survival of GM-CSF dependent rat GMIR1-microglial cells.

Kayvon Salimi1, Karma Moser, Birgit Zassler, Markus Reindl, Norbert Embacher, Christine Schermer, Carla Weis, Josef Marksteiner, Makoto Sawada, Christian Humpel.   

Abstract

Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-colony stimulating factor (GM-CSF). Endogenous GDNF and its receptor, GFRalpha-1, were detected in GMIR1 cells by ELISA and immunohistochemistry/Western blot, respectively. Recombinant GDNF strongly enhanced GMIR1 cell numbers and BrdU-incorporation, an effect inhibited by GDNF blocking antibodies. Inhibition of cAMP/cGMP dependent protein kinase enhanced the GDNF-induced GMIR1 cell number. The results suggest that GDNF has synergistic survival promoting effects on microglia potentially via autocrine mechanisms.

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Year:  2002        PMID： 12103440     DOI： 10.1016/s0168-0102(02)00036-6

Source DB:  PubMed          Journal:  Neurosci Res        ISSN： 0168-0102            Impact factor:   3.304


  6 in total

1.  Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia.

Authors:  Tadashi Matsuura; Takashi Mori; Megumi Hasaka; Miyuki Kuno; Junko Kawawaki; Kiyonobu Nishikawa; Toshio Narahashi; Makoto Sawada; Akira Asada
Journal:  J Physiol       Date:  2011-12-19       Impact factor: 5.182

2.  Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state.

Authors:  T Matsumura; A Sakai; M Nagano; M Sawada; H Suzuki; M Umino; H Suzuki
Journal:  Br J Pharmacol       Date:  2008-07-28       Impact factor: 8.739

3.  Increases in intracellular pH facilitate endocytosis and decrease availability of voltage-gated proton channels in osteoclasts and microglia.

Authors:  Hiromu Sakai; Guangshuai Li; Yoshiko Hino; Yoshie Moriura; Junko Kawawaki; Makoto Sawada; Miyuki Kuno
Journal:  J Physiol       Date:  2013-09-30       Impact factor: 5.182

4.  Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms.

Authors:  Hirokazu Morihata; Junko Kawawaki; Masako Okina; Hiromu Sakai; Takuya Notomi; Makoto Sawada; Miyuki Kuno
Journal:  Pflugers Arch       Date:  2007-09-18       Impact factor: 3.657

Review 5.  Kidney dysfunction in patients with pulmonary arterial hypertension.

Authors:  N P Nickel; J M O'Leary; E L Brittain; J P Fessel; R T Zamanian; J D West; E D Austin
Journal:  Pulm Circ       Date:  2017-03-13       Impact factor: 3.017

Review 6.  Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system.

Authors:  Nils Lannes; Elisabeth Eppler; Samar Etemad; Peter Yotovski; Luis Filgueira
Journal:  Oncotarget       Date:  2017-12-11
  6 in total

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