| Literature DB >> 12103291 |
James R Johnson1, Amee R Manges, Timothy T O'Bryan, Lee W Riley.
Abstract
In acute pyelonephritis, bacterial resistance to co-trimoxazole predicts treatment failure, but the clonal basis of such resistance is undefined. We did molecular and serological analyses of 170 Escherichia coli urine isolates obtained in 1994-96 from women with acute pyelonephritis. 12 (7%) of the pyelonephritis isolates were in clonal group A (CGA; responsible for 38-51% of co-trimoxazole resistance in acute cystitis), including ten (34%) of 29 isolates that were resistant to co-trimoxazole. CGA isolates were obtained from diverse locations across the USA and were related to the O15:K52:H1 clone of the 1986-87 outbreak in London, UK. Thus, CGA is broadly disseminated and contributes to co-trimoxazole resistance in pyelonephritis as well as in cystitis.Entities:
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Year: 2002 PMID： 12103291 DOI： 10.1016/S0140-6736(02)09264-4
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321