| Literature DB >> 12100135 |
Christian Flotho1, Brigitte Strahm, Udo Kontny, Ulrich Duffner, Anke M J Peters, Wolfgang Dupuis, Charlotte M Niemeyer.
Abstract
Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic disorder characterized by chronic or intermittent intravascular haemolysis, variable cytopenia and an increased risk of thrombosis. Stem cell transplantation (SCT) is a curative therapeutic option, but its risks must be carefully weighed against the natural course of PNH. World-wide experience with SCT for PNH in the paediatric age group is scarce. We report on two adolescents suffering from PNH with life-threatening complications who were successfully transplanted from unrelated donors. Indications and techniques of SCT in childhood PNH are discussed and an overview of the literature is given.Entities:
Mesh：
Year: 2002 PMID： 12100135 DOI： 10.1046/j.1365-2141.2002.03543.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998