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Literature DB >> 12099372

Cytomegalovirus (CMV) resistance to antivirals.

Abstract

This article reviews the biology of cytomegalovirus (CMV), the approved antiviral therapies, and mechanisms of resistance to these drugs. The rates of resistance development in clinical trials are presented, as are the assays for testing susceptibility by phenotypic and genotypic methods. Factors that favor the development of clinical and in vitro antiviral resistance are discussed. Finally, approaches to altering antiviral therapy as resistance develops are outlined.

Entities: Disease

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Year: 2001 PMID： 12099372

Source DB: PubMed Journal: Am J Transplant ISSN： 1600-6135 Impact factor: 8.086

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Cited

13 in total

1. Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet.

Authors: Egor P Tchesnokov; Christian Gilbert; Guy Boivin; Matthias Götte
Journal: J Virol Date: 2006-02 Impact factor: 5.103

2. Novel real-time monitoring system for human cytomegalovirus-infected cells in vitro that uses a green fluorescent protein-PML-expressing cell line.

Authors: T Ueno; Y Eizuru; H Katano; T Kurata; T Sata; S Irie; K Ogawa-Goto
Journal: Antimicrob Agents Chemother Date: 2006-08 Impact factor: 5.191

3. Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89.

Authors: Brian G Gentry; Quang Phan; Ellie D Hall; Julie M Breitenbach; Katherine Z Borysko; Jeremy P Kamil; Leroy B Townsend; John C Drach
Journal: Antimicrob Agents Chemother Date: 2014-10-27 Impact factor: 5.191

Cytomegalovirus (CMV) resistance to antivirals.

1. Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet.

2. Novel real-time monitoring system for human cytomegalovirus-infected cells in vitro that uses a green fluorescent protein-PML-expressing cell line.

3. Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89.

Review 4. Update on human herpesvirus 6 biology, clinical features, and therapy.

5. Gastrointestinal Infections Caused by Cytomegalovirus.

6. Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus.

7. Specific inhibition of human cytomegalovirus glycoprotein B-mediated fusion by a novel thiourea small molecule.

Review 8. Viral infection after renal transplantation: surveillance and management.

Review 9. Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation.

10. Pentostatin antagonizes the antiviral activity of MBX-2168 by inhibiting the biosynthesis of the active compound.