Early Expression of Protooncogenes Induced by the Binding to Cells of Two Viruses.

The specific binding of virus to receptor is essentially the interaction of ligand and receptor. This binding is able to induce cellular primary gene response that has various regulatory function in cells. Different immediate-early gene responses could be induced with different binding virus. The different gene responses were observed as poliovirus and HSV-I bind to human diploid cells. These differences showed that early expression of protooncogenes were enhanced and/or suppressed in the primary gene responses.