Literature DB >> 12097559

Avian and Mammalian hepadnaviruses have distinct transcription factor requirements for viral replication.

Hong Tang1, Alan McLachlan.   

Abstract

Hepadnavirus replication occurs in hepatocytes in vivo and in hepatoma cell lines in cell culture. Hepatitis B virus (HBV) replication can occur in nonhepatoma cells when pregenomic RNA synthesis from viral DNA is activated by the expression of the nuclear hormone receptors hepatocyte nuclear factor 4 (HNF4) and the retinoid X receptor alpha (RXR alpha) plus peroxisome proliferator-activated receptor alpha (PPAR alpha) heterodimer. Nuclear hormone receptor-dependent HBV replication is inhibited by hepatocyte nuclear factor 3 (HNF3). In contrast, HNF3 and HNF4 support duck hepatitis B virus (DHBV) replication in nonhepatoma cells, whereas the RXR alpha-PPAR alpha heterodimer inhibits HNF4-dependent DHBV replication. HNF3 and HNF4 synergistically activate DHBV pregenomic RNA synthesis and viral replication. The conditions that support HBV or DHBV replication in nonhepatoma cells are not able to support woodchuck hepatitis virus replication. These observations indicate that avian and mammalian hepadnaviruses have distinct transcription factor requirements for viral replication.

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Year:  2002        PMID： 12097559      PMCID： PMC136384          DOI： 10.1128/jvi.76.15.7468-7472.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  46 in total

1.  Frequency of spontaneous mutations in an avian hepadnavirus infection.

Authors:  I Pult; N Abbott; Y Y Zhang; J Summers
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

2.  A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.

Authors:  J Summers; J M Smolec; R Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

3.  Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus.

Authors:  W S Mason; G Seal; J Summers
Journal:  J Virol       Date:  1980-12       Impact factor: 5.103

4.  Identification of hepatitis B virus indigenous to chimpanzees.

Authors:  X Hu; H S Margolis; R H Purcell; J Ebert; B H Robertson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

5.  A new avian hepadnavirus infecting snow geese (Anser caerulescens) produces a significant fraction of virions containing single-stranded DNA.

Authors:  S F Chang; H J Netter; M Bruns; R Schneider; K Frölich; H Will
Journal:  Virology       Date:  1999-09-15       Impact factor: 3.616

6.  Characterization of a functional hepatocyte nuclear factor 3 binding site in the hepatitis B virus nucleocapsid promoter.

Authors:  J L Johnson; A K Raney; A McLachlan
Journal:  Virology       Date:  1995-04-01       Impact factor: 3.616

7.  Identification and analysis of a new hepadnavirus in white storks.

Authors:  I Pult; H J Netter; M Bruns; A Prassolov; H Sirma; H Hohenberg; S F Chang; K Frölich; O Krone; E F Kaleta; H Will
Journal:  Virology       Date:  2001-10-10       Impact factor: 3.616

8.  A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.

Authors:  P L Marion; L S Oshiro; D C Regnery; G H Scullard; W S Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

9.  Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA.

Authors:  M F Dubois; C Pourcel; S Rousset; C Chany; P Tiollais
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

10.  Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism.

Authors:  H Tang; A McLachlan
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-06       Impact factor: 11.205
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  6 in total

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Journal:  J Virol       Date:  2006-06       Impact factor: 5.103

2.  Replication of hepatitis B virus in primary duck hepatocytes transfected with linear viral DNA.

Authors:  Yun-Qing Yao; Ding-Feng Zhang; Ni Tang; Ai-Long Huang; Xiao-Yi Zou; Jiang-Feng Xiao; Yun Luo; Da-Zhi Zhang; Bo Wang; Wei-Ping Zhou; Hong Ren; Qi Liu; Shu-Hua Guo
Journal:  World J Gastroenterol       Date:  2005-08-28       Impact factor: 5.742

3.  Application of hepatitis B virus replication mouse model.

Authors:  Zhan Gao; Feng-Jun Liu; Li Liu; Tao-You Zhou; Jun Lei; Lu Xu; Cong Liu; Jie Dai; En-Qiang Chen; Hong Tang
Journal:  World J Gastroenterol       Date:  2010-04-28       Impact factor: 5.742

4.  Establishment and primary application of a mouse model with hepatitis B virus replication.

Authors:  Feng-Jun Liu; Li Liu; Fang He; Su Wang; Tao-You Zhou; Cong Liu; Lin-Yu Deng; Hong Tang
Journal:  World J Gastroenterol       Date:  2007-10-28       Impact factor: 5.742

5.  Heterologous replacement of the supposed host determining region of avihepadnaviruses: high in vivo infectivity despite low infectivity for hepatocytes.

Authors:  Kai Dallmeier; Ursula Schultz; Michael Nassal
Journal:  PLoS Pathog       Date:  2008-12-05       Impact factor: 6.823

6.  Cisplatin Enhances Hepatitis B Virus Replication and PGC-1α Expression through Endoplasmic Reticulum Stress.

Authors:  Xiaosong Li; E Pan; Junke Zhu; Lei Xu; Xuemei Chen; Jingjing Li; Li Liang; Yuan Hu; Jie Xia; Juan Chen; Wannan Chen; Jieli Hu; Kai Wang; Ni Tang; Ailong Huang
Journal:  Sci Rep       Date:  2018-02-22       Impact factor: 4.379
  6 in total

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