Literature DB >> 12097508

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.

Neil Collinson1, Frederick M Kuenzi, Wolfgang Jarolimek, Karen A Maubach, Rosa Cothliff, Cyrille Sur, Alison Smith, Franklin M Otu, Owain Howell, John R Atack, Ruth M McKernan, Guy R Seabrook, Gerry R Dawson, Paul J Whiting, Thomas W Rosahl.   

Abstract

The alpha5 subunit of the GABA(A) receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct localization and the function of alpha5-containing GABA(A) receptors has been explored by targeted disruption of the alpha5 gene in mice. The alpha5 -/- mice showed a significantly improved performance in a water maze model of spatial learning, whereas the performance in non-hippocampal-dependent learning and in anxiety tasks were unaltered in comparison with wild-type controls. In the CA1 region of hippocampal brain slices from alpha5 -/- mice, the amplitude of the IPSCs was decreased, and paired-pulse facilitation of field EPSP (fEPSP) amplitudes was enhanced. These data suggest that alpha5-containing GABA(A) receptors play a key role in cognitive processes by controlling a component of synaptic transmission in the CA1 region of the hippocampus.

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Year:  2002        PMID： 12097508      PMCID： PMC6758233          DOI： 20026436

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  45 in total

1.  Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain.

Authors:  C Sur; L Fresu; O Howell; R M McKernan; J R Atack
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Review 4.  Which GABAA-receptor subtypes really occur in the brain?

Authors:  R M McKernan; P J Whiting
Journal:  Trends Neurosci       Date:  1996-04       Impact factor: 13.837

5.  GABA(A) receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits.

Authors:  G Sperk; C Schwarzer; K Tsunashima; K Fuchs; W Sieghart
Journal:  Neuroscience       Date:  1997-10       Impact factor: 3.590

6.  The use of a plus-maze to measure anxiety in the mouse.

Authors:  R G Lister
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

7.  Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice.

Authors:  C Sur; K A Wafford; D S Reynolds; K L Hadingham; F Bromidge; A Macaulay; N Collinson; G O'Meara; O Howell; R Newman; J Myers; J R Atack; G R Dawson; R M McKernan; P J Whiting; T W Rosahl
Journal:  J Neurosci       Date:  2001-05-15       Impact factor: 6.167

8.  Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues.

Authors:  F Crestani; M Lorez; K Baer; C Essrich; D Benke; J P Laurent; C Belzung; J M Fritschy; B Lüscher; H Mohler
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9.  Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome.

Authors:  T M DeLorey; A Handforth; S G Anagnostaras; G E Homanics; B A Minassian; A Asatourian; M S Fanselow; A Delgado-Escueta; G D Ellison; R W Olsen
Journal:  J Neurosci       Date:  1998-10-15       Impact factor: 6.167

10.  Short-term synaptic plasticity is altered in mice lacking synapsin I.

Authors:  T W Rosahl; M Geppert; D Spillane; J Herz; R E Hammer; R C Malenka; T C Südhof
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  194 in total

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4.  An inverse agonist selective for alpha5 subunit-containing GABAA receptors improves encoding and recall but not consolidation in the Morris water maze.

Authors:  N Collinson; J R Atack; P Laughton; G R Dawson; D N Stephens
Journal:  Psychopharmacology (Berl)       Date:  2006-04-22       Impact factor: 4.530

5.  Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses.

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Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-06       Impact factor: 11.205

6.  Timing and balance of inhibition enhance the effect of long-term potentiation on cell firing.

Authors:  Carrie P Marder; Dean V Buonomano
Journal:  J Neurosci       Date:  2004-10-06       Impact factor: 6.167

7.  Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition.

Authors:  Timothy B Johnstone; Zhenglin Gu; Ryan F Yoshimura; Anne-Sophie Villegier; Derk J Hogenkamp; Edward R Whittemore; Jin-Cheng Huang; Minhtam B Tran; James D Belluzzi; Jerrel L Yakel; Kelvin W Gee
Journal:  J Pharmacol Exp Ther       Date:  2010-12-15       Impact factor: 4.030

8.  The GABAergic deficit hypothesis of major depressive disorder.

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9.  Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.

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Journal:  Neuropharmacology       Date:  2010-08-18       Impact factor: 5.250

10.  GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.

Authors:  Ewa D Zarnowska; Ruth Keist; Uwe Rudolph; Robert A Pearce
Journal:  J Neurophysiol       Date:  2008-12-10       Impact factor: 2.714
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