| Literature DB >> 1209648 |
Abstract
An acute intoxication by lead chloride (conc. 2.5 - 10(-4)M) produces a temporary reduction of macromolecular syntheses in HeLa cells growing asynchronously. The reduction is similar for DNA, RNA and proteins and differs only in the intensity. After a one-day intoxication, if the cells are put back in a fresh medium, the syntheses return to normal within 10 h. The histochemical sulphide-silver method shows that lead is present in the cells during the inhibition.Entities:
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Year: 1975 PMID： 1209648 DOI： 10.1016/0300-483x(75)90114-6
Source DB: PubMed Journal: Toxicology ISSN： 0300-483X Impact factor: 4.221