Literature DB >> 12096217

Microtubule-actin cross-talk at focal adhesions.

Alexander F Palazzo1, Gregg G Gundersen.   

Abstract

Focal adhesions are dynamic structures in which traction forces are exerted against the substratum during cell migration and are sites for the organization of signaling complexes. Palazzo and Gundersen discuss how focal adhesions may also be the site of cross-talk between the actin-based and microtubule-based cytoskeletons. Microtubules appear to deliver factors that can regulate the formation and dissolution of focal adhesions, whereas focal adhesions contribute to microtubule localization and stability.

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Year:  2002        PMID： 12096217     DOI： 10.1126/stke.2002.139.pe31

Source DB:  PubMed          Journal:  Sci STKE        ISSN： 1525-8882


  22 in total

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