Literature DB >> 12095627

Protein disulfide isomerase of Toxoplasma gondii is targeted by mucosal IgA antibodies in humans.

Bob Meek1, Jaap Willem Back, Vincent N A Klaren, Dave Speijer, Ron Peek.   

Abstract

Mass spectrometric analysis identified a 49 kDa antigen from Toxoplasma gondii as protein disulfide isomerase (PDI). This antigen is generally recognized by IgA in tears of healthy humans. We determined the complete open reading frame and expressed PDI recombinantly. Recombinant PDI was recognized by IgA in human tears known to contain antibodies specific for the 49 kDa antigen. High expression level and similarity to other protozoan PDIs suggest that T. gondii PDI might be a suitable target for recently described anti-protozoan drugs. PDI-specific antibodies clearly constitute part of the mucosal antibody repertoire possibly involved in defence against parasites.

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Year:  2002        PMID： 12095627     DOI： 10.1016/s0014-5793(02)02911-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Molecular cloning, expression, and immunolocalization of protein disulfide isomerase in excretory-secretory products from Clonorchis sinensis.

Authors:  Yue Hu; Lisi Huang; Yan Huang; Lei He; Fan Zhang; Wenfang Li; Pei Liang; Ran Li; Jiufeng Sun; Xiaoyun Wang; Chi Liang; Xuerong Li; Xinbing Yu
Journal:  Parasitol Res       Date:  2012-04-27       Impact factor: 2.289

2.  The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasion and survival proteins.

Authors:  Xing W Zhou; Björn F C Kafsack; Robert N Cole; Phil Beckett; Rong F Shen; Vern B Carruthers
Journal:  J Biol Chem       Date:  2005-07-07       Impact factor: 5.157

3.  A Purification Method for Enrichment of the Toxoplasma gondii Cyst Wall.

Authors:  Yi Wei Zhang; Sandra K Halonen; Yan Fen Ma; Herbert B Tanowtiz; Louis M Weiss
Journal:  J Neuroparasitology       Date:  2010-12

4.  Identification of the cross-reactive and species-specific antigens between Neospora caninum and Toxoplasma gondii tachyzoites by a proteomics approach.

Authors:  Houshuang Zhang; Eung-Goo Lee; Longzheng Yu; Suguru Kawano; Penglong Huang; Min Liao; Osamu Kawase; Guohong Zhang; Jinlin Zhou; Kozo Fujisaki; Yoshifumi Nishikawa; Xuenan Xuan
Journal:  Parasitol Res       Date:  2011-04-02       Impact factor: 2.289

5.  A Role for Basigin in Toxoplasma gondii Infection.

Authors:  Azadeh Nasuhidehnavi; Yanlin Zhao; Ankita Punetha; Andrew Hemphill; Hong Li; Tyler J Bechtel; Theresa Rager; Bingcong Xiong; Vasileios I Petrou; Marc-Jan Gubbels; Eranthie Weerapana; George S Yap
Journal:  Infect Immun       Date:  2022-08-01       Impact factor: 3.609

6.  Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome.

Authors:  Kalpana Lal; Judith Helena Prieto; Elizabeth Bromley; Sanya J Sanderson; John R Yates; Jonathan M Wastling; Fiona M Tomley; Robert E Sinden
Journal:  Proteomics       Date:  2009-03       Impact factor: 3.984

7.  Identification and enzymatic activities of four protein disulfide isomerase (PDI) isoforms of Leishmania amazonensis.

Authors:  B X Hong; L Soong
Journal:  Parasitol Res       Date:  2007-12-06       Impact factor: 2.289

Review 8.  Protein disulfide isomerase and host-pathogen interaction.

Authors:  Beatriz S Stolf; Ioannis Smyrnias; Lucia R Lopes; Alcione Vendramin; Hiro Goto; Francisco R M Laurindo; Ajay M Shah; Celio X C Santos
Journal:  ScientificWorldJournal       Date:  2011-10-18

9.  Evaluation of Leishmania donovani protein disulfide isomerase as a potential immunogenic protein/vaccine candidate against visceral Leishmaniasis.

Authors:  Pramod Kumar Kushawaha; Reema Gupta; Chandra Dev Pati Tripathi; Shyam Sundar; Anuradha Dube
Journal:  PLoS One       Date:  2012-04-23       Impact factor: 3.240

10.  The protein disulfide isomerase 1 of Phytophthora parasitica (PpPDI1) is associated with the haustoria-like structures and contributes to plant infection.

Authors:  Yuling Meng; Qiang Zhang; Meixiang Zhang; Biao Gu; Guiyan Huang; Qinhu Wang; Weixing Shan
Journal:  Front Plant Sci       Date:  2015-08-18       Impact factor: 5.753
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