BACKGROUND: The presence of macroscopically multiple ipsilateral invasive breast cancer (MMIIBC) has been considered a contraindication for breast conservation. Early series reported high rates of local recurrence. A treatment regimen was developed to accommodate patient requests for breast conservation in MMIIBC. METHODS: We reviewed medical records of the 15 MMIIBC patients who underwent partial mastectomy followed by radiation between 1989 and 1997. All patients had 2 or more separate macroscopic tumors greater than 2 mm in diameter. After tumor excision, all specimens were evaluated; the protocol required surgical margins of at least 2 mm. RESULTS: As of June 2000 (median follow-up 76 months), 14 patients (93%) were alive without evidence of disease. One patient died of systemic disease without local recurrence. CONCLUSIONS: In selected cases, the combination of breast conservative surgery and radiation therapy with systemic therapy results in acceptable local-regional control. Patients who present with MMIIBC with clear surgical margins should be considered for breast conservation.
BACKGROUND: The presence of macroscopically multiple ipsilateral invasive breast cancer (MMIIBC) has been considered a contraindication for breast conservation. Early series reported high rates of local recurrence. A treatment regimen was developed to accommodate patient requests for breast conservation in MMIIBC. METHODS: We reviewed medical records of the 15 MMIIBC patients who underwent partial mastectomy followed by radiation between 1989 and 1997. All patients had 2 or more separate macroscopic tumors greater than 2 mm in diameter. After tumor excision, all specimens were evaluated; the protocol required surgical margins of at least 2 mm. RESULTS: As of June 2000 (median follow-up 76 months), 14 patients (93%) were alive without evidence of disease. One patient died of systemic disease without local recurrence. CONCLUSIONS: In selected cases, the combination of breast conservative surgery and radiation therapy with systemic therapy results in acceptable local-regional control. Patients who present with MMIIBC with clear surgical margins should be considered for breast conservation.
Authors: Kari M Rosenkranz; Karla Ballman; Linda McCall; Charlotte Kubicky; Laurie Cuttino; Huong Le-Petross; Kelly K Hunt; Armando Giuliano; Kimberly J Van Zee; Bruce Haffty; Judy C Boughey Journal: Ann Surg Oncol Date: 2018-07-09 Impact factor: 5.344
Authors: Kari M Rosenkranz; Karla Ballman; Linda McCall; Colleen McCarthy; Charlotte D Kubicky; Laurie Cuttino; Kelly K Hunt; Armando Giuliano; Kimberly J Van Zee; Bruce Haffty; Judy C Boughey Journal: Ann Surg Oncol Date: 2020-07-22 Impact factor: 5.344
Authors: Chaitanyanand B Koppiker; Aijaz Ul Noor; Santosh Dixit; Laleh Busheri; Gautam Sharan; Upendra Dhar; Hari Kiran Allampati; Smeeta Nare Journal: Int J Breast Cancer Date: 2019-02-20
Authors: Laurie W Cuttino; Linda McCall; Charlotte Kubicky; Karla V Ballman; Huong Le-Petross; Kelly K Hunt; Bruce Haffty; Kari M Rosenkranz; Judy C Boughey Journal: Int J Radiat Oncol Biol Phys Date: 2021-10-08 Impact factor: 7.038
Authors: Z E Winters; J Horsnell; K T Elvers; A J Maxwell; L J Jones; A M Shaaban; P Schmid; N R Williams; A Beswick; R Greenwood; J C Ingram; C Saunders; J S Vaidya; L Esserman; I Jatoi; A M Brunt Journal: BJS Open Date: 2018-05-22