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Literature DB >> 12094239

LKB1--a master tumour suppressor of the small intestine and beyond.

Lina I Yoo¹, Daniel C Chung, Junying Yuan.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2002 PMID： 12094239 DOI： 10.1038/nrc843

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

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Cited

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38 in total

1. The Snf1 protein kinase and Sit4 protein phosphatase have opposing functions in regulating TATA-binding protein association with the Saccharomyces cerevisiae INO1 promoter.

Authors: Margaret K Shirra; Sarah E Rogers; Diane E Alexander; Karen M Arndt
Journal: Genetics Date: 2005-02-16 Impact factor: 4.562

2. Regulation of protein synthesis by ionizing radiation.

Authors: Steve Braunstein; Michelle L Badura; Qiaoran Xi; Silvia C Formenti; Robert J Schneider
Journal: Mol Cell Biol Date: 2009-08-24 Impact factor: 4.272

3. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability.

Authors: Jérôme Boudeau; Maria Deak; Margaret A Lawlor; Nick A Morrice; Dario R Alessi
Journal: Biochem J Date: 2003-03-15 Impact factor: 3.857

4. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

Authors: Gopal P Sapkota; Maria Deak; Agnieszka Kieloch; Nick Morrice; Aaron A Goodarzi; Carl Smythe; Yosef Shiloh; Susan P Lees-Miller; Dario R Alessi
Journal: Biochem J Date: 2002-12-01 Impact factor: 3.857

5. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

Authors: Jérôme Boudeau; Annette F Baas; Maria Deak; Nick A Morrice; Agnieszka Kieloch; Mike Schutkowski; Alan R Prescott; Hans C Clevers; Dario R Alessi
Journal: EMBO J Date: 2003-10-01 Impact factor: 11.598

LKB1--a master tumour suppressor of the small intestine and beyond.

1. The Snf1 protein kinase and Sit4 protein phosphatase have opposing functions in regulating TATA-binding protein association with the Saccharomyces cerevisiae INO1 promoter.

2. Regulation of protein synthesis by ionizing radiation.

3. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability.

4. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

5. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

6. Restoration of silenced Peutz-Jeghers syndrome gene, LKB1, induces apoptosis in pancreatic carcinoma cells.

7. Novel mutations in the STK11 gene in Thai patients with Peutz-Jeghers syndrome.

8. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.

Review 9. An exploration of genotype-phenotype link between Peutz-Jeghers syndrome and STK11: a review.

10. Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.