Literature DB >> 12093696

In vitro assessment of antiborrelial activity of OspA vaccine sera.

Paul T Fawcett1, Carlos D Rose, Kathleen M Gibney.   

Abstract

Prevention of Lyme disease by the recombinant OspA-based vaccine reportedly works by preventing transmission of spirochetes from ticks to humans. We report on an in vitro microculture assay, which can be used to provide an indicator of the need for booster doses of vaccine.

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Year:  2002        PMID： 12093696      PMCID： PMC120022          DOI： 10.1128/cdli.9.4.919-920.2002

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  13 in total

1.  Borreliacidal activity of early Lyme disease sera against complement-resistant Borrelia afzelii FEM1 wild-type and an OspC-lacking FEM1 variant.

Authors:  Peter Kraiczy; Klaus-Peter Hunfeld; Stefan Peters; Reinhard Würzner; Georg Acker; Bettina Wilske; Volker Brade
Journal:  J Med Microbiol       Date:  2000-10       Impact factor: 2.472

2.  Frequency and specificity of antibodies that crossreact with Borrelia burgdorferi antigens.

Authors:  P T Fawcett; K M Gibney; C D Rose; S B Dubbs; R A Doughty
Journal:  J Rheumatol       Date:  1992-04       Impact factor: 4.666

3.  Killing of Borrelia burgdorferi by antibody elicited by OspA vaccine is inefficient in the absence of complement.

Authors:  J M Nowling; M T Philipp
Journal:  Infect Immun       Date:  1999-01       Impact factor: 3.441

4.  Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes.

Authors:  Brian Stevenson; Nazira El-Hage; Melissa A Hines; Jennifer C Miller; Kelly Babb
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

5.  Effect of immunization with recombinant OspA on serologic tests for Lyme borreliosis.

Authors:  P T Fawcett; C D Rose; S M Budd; K M Gibney
Journal:  Clin Diagn Lab Immunol       Date:  2001-01

6.  Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.

Authors:  E Fikrig; S R Telford; S W Barthold; F S Kantor; A Spielman; R A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

7.  Detection of borreliacidal antibodies by flow cytometry. An accurate, highly specific serodiagnostic test for Lyme disease.

Authors:  S M Callister; R F Schell; L C Lim; D A Jobe; K L Case; G L Bryant; P E Molling
Journal:  Arch Intern Med       Date:  1994-07-25

8.  In vitro inhibition of Borrelia burgdorferi growth by antibodies.

Authors:  A Sadziene; P A Thompson; A G Barbour
Journal:  J Infect Dis       Date:  1993-01       Impact factor: 5.226

9.  A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein.

Authors:  A Sadziene; M Jonsson; S Bergström; R K Bright; R C Kennedy; A G Barbour
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

10.  Antiborrelial activity of serum from rats injected with the Lyme disease spirochete.

Authors:  C S Pavia; V Kissel; S Bittker; F Cabello; S Levine
Journal:  J Infect Dis       Date:  1991-03       Impact factor: 5.226
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