Literature DB >> 12093008

No one is naive: the significance of heterologous T-cell immunity.

Raymond M Welsh1, Liisa K Selin.   

Abstract

Memory T cells that are specific for one virus can become activated during infection with an unrelated heterologous virus, and might have roles in protective immunity and immunopathology. The course of each infection is influenced by the T-cell memory pool that has been laid down by a host's history of previous infections, and with each successive infection, T-cell memory to previously encountered agents is modified. Here, we discuss evidence from studies in mice and humans that shows the importance of this phenomenon in determining the outcome of infection.

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Year:  2002        PMID: 12093008     DOI: 10.1038/nri820

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN: 1474-1733            Impact factor:   53.106


  187 in total

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7.  Non-specific effects of vaccination: vaccines have non-specific (heterologous) effects.

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Journal:  BMJ       Date:  2005-04-09

8.  Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity.

Authors:  Markus Cornberg; Alex T Chen; Lee A Wilkinson; Michael A Brehm; Sung-Kwon Kim; Claudia Calcagno; Dario Ghersi; Roberto Puzone; Franco Celada; Raymond M Welsh; Liisa K Selin
Journal:  J Clin Invest       Date:  2006-04-13       Impact factor: 14.808

9.  Immunodominant "asymptomatic" herpes simplex virus 1 and 2 protein antigens identified by probing whole-ORFome microarrays with serum antibodies from seropositive asymptomatic versus symptomatic individuals.

Authors:  Gargi Dasgupta; Aziz A Chentoufi; Mina Kalantari; Payam Falatoonzadeh; Sookhee Chun; Chang Hyun Lim; Philip L Felgner; D Huw Davies; Lbachir BenMohamed
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10.  Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry.

Authors:  Markus Cornberg; Brian S Sheridan; Frances M Saccoccio; Michael A Brehm; Liisa K Selin
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

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