Literature DB >> 12092843

Hypoglycemic effect of a Lentinus edodes exo-polymer produced from a submerged mycelial culture.

Byung-Keun Yang1, Dong-Hyun Kim, Sang-Chul Jeong, Surajit Das, Young-Sun Choi, Joon-Shik Shin, Sang-Chul Lee, Chi-Hyun Song.   

Abstract

The hypoglycemic effect of an exo-polymer produced from a submerged mycelial culture of Lentinus edodes was investigated in streptozotocin-induced diabetic rats. The administration of the exo-polymer (200 mg/kg BW) reduced the plasma glucose level by as much as 21.5%, and increased plasma insulin by 22.1% as compared to the control group. It also lowered the plasma total cholesterol and triglyceride levels by 25.1 and 44.5%, respectively. Gel chromatography of the exo-polymer revealed a single peak which is likely to have been a glycoprotein with a molecular weight of 52 kDa and was found to contain 83.5% carbohydrate and 16.5% protein. The Sugar and amino acid compositions of the exo-polymer were analyzed in detail.

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Year:  2002        PMID： 12092843     DOI： 10.1271/bbb.66.937

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  8 in total

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Review 4.  Anti-Obesity Effects of Medicinal and Edible Mushrooms.

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6.  Selenium-Containing Exopolysaccharides Isolated from the Culture Medium of Lentinula edodes: Structure and Biological Activity.

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  8 in total

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