Literature DB >> 12092825

Characterization of cloned mouse Na+/taurocholate cotransporting polypeptide by transient expression in COS-7 cells.

Tohru Saeki1, Noriki Takahashi, Ryuhei Kanamoto, Kimikazu Iwami.   

Abstract

The mouse Na+/taurocholate cotransporting polypeptide transiently expressed in COS-7 cells caused sodium-dependent uptake of [3H]taurocholic acid with Km and Vmax values of 18 microM and 102 pmol/mg protein/min, respectively. This Km value is comparable to that for rat NTCP and higher than that for human NTCP. Substrate specificity was evaluated by measuring inhibitory effects of unlabeled bile acids on [3H]taurocholic acid transport.

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Year:  2002        PMID： 12092825     DOI： 10.1271/bbb.66.1116

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  5 in total

1.  Gastric antisecretory and antiulcer activity of bovine hemoglobin.

Authors:  Abdulrahman K Al Asmari; Saud Al Omani; Ibrahim Elfaki; Mohammad Tariq; Ahmed Al Malki; Saeed Al Asmary
Journal:  World J Gastroenterol       Date:  2013-06-07       Impact factor: 5.742

2.  A substrate pharmacophore for the human sodium taurocholate co-transporting polypeptide.

Authors:  Zhongqi Dong; Sean Ekins; James E Polli
Journal:  Int J Pharm       Date:  2014-11-13       Impact factor: 5.875

3.  Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes.

Authors:  Brandon Swift; Kim L R Brouwer
Journal:  Mol Pharm       Date:  2010-04-05       Impact factor: 4.939

Review 4.  Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

Authors:  Curtis D Klaassen; Lauren M Aleksunes
Journal:  Pharmacol Rev       Date:  2010-01-26       Impact factor: 25.468

5.  Staurosporine synergistically potentiates the deoxycholate-mediated induction of COX-2 expression.

Authors:  Tohru Saeki; Haruka Inui; Saya Fujioka; Suguru Fukuda; Ayumi Nomura; Yasushi Nakamura; Eun Young Park; Kenji Sato; Ryuhei Kanamoto
Journal:  Physiol Rep       Date:  2014-08-28
  5 in total

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