Decreased expression of TGF-beta type 2 receptor in primary B-cell lymphomas of the stomach.

TGF-beta insensitivity has been reported in some malignant lymphomas showing loss of TGF-beta receptor expression. This loss of TGF-beta sensitivity is thought to have removed the immunosuppressive properties of TGF-beta, thus enhancing cell proliferation and resulting in the development of malignant lymphoma. In this study, we performed immunohistochemical stains for TGF-beta1, TGF-beta RI and TGF-beta RII in primary gastric B-cell lymphomas in order to ascertain their possible roles in lymphomagenesis. A total of twenty cases of gastric lymphoma were included. All cases of low- and high-grade lymphomas were negative or weakly positive for TGF-beta1. Reactive lymphoid cells, including the germinal center, were also negative for TGF-beta1. In contrast, reactive germinal centers showed moderate to strong cytoplasmic or membranous staining for TGF-beta RI and TGF-beta RII. In malignant lymphomas, TGF-beta RI expression was maintained in all cases of low- and high-grade lymphomas. In contrast, TGF-beta RII expression was decreased in all low- and high-grade lymphoma cells. These findings suggest that the loss of TGF-beta RII expression may be involved in the lymphomagenesis of the stomach.