Literature DB >> 12090722

Miltefosine Zentaris.

Ronald Kaminsky1.   

Abstract

Zentaris (formerly Asta Medica) has developed and launched miltefosine, a phospholipid derivative, in various European countries [173324], [254947] and in Brazil in 1997 [332428], [366795] as a treatment for breast cancer. As of January 2002, phase III trials for treatment of leishmaniaisis were ongoing [435767]. In February 1999, Lehman Brothers predicted miltefosine would be launched for treatment of leishmaniasis in 2002, with peak sales expected in 2010 [319225].

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Year:  2002        PMID: 12090722

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN: 1472-4472


  2 in total

1.  Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.

Authors:  Fred Widmer; Lesley C Wright; Daniel Obando; Rosemary Handke; Ranjini Ganendren; David H Ellis; Tania C Sorrell
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

2.  Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri.

Authors:  Wenxu Zhou; Anjan Debnath; Gareth Jennings; Hye Jee Hahn; Boden H Vanderloop; Minu Chaudhuri; W David Nes; Larissa M Podust
Journal:  PLoS Pathog       Date:  2018-09-13       Impact factor: 6.823

  2 in total

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