| Literature DB >> 12090462 |
Gregor Cicchetti1, Philip G Allen, Michael Glogauer.
Abstract
In this review, we present an overview of the signaling elements between neutrophil chemotactic receptors and the actin cytoskeleton that drives cell motility. From receptor-ligand interactions, activation of heterotrimeric G-proteins, their downstream effectors PLC and PI-3 kinase, the activation of small GTPases of the Rho family, and their regulation of particular cytoskeletal regulatory proteins, we describe pathways specific to the chemotaxing neutrophil and elements documented to be important for neutrophil function.Entities:
Keywords: Non-programmatic
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Year: 2002 PMID： 12090462 DOI： 10.1177/154411130201300302
Source DB: PubMed Journal: Crit Rev Oral Biol Med ISSN： 1045-4411