Literature DB >> 12089470

Carbon - the first frontier of information processing.

Apoorva Patel1.   

Abstract

Information is often encoded as an aperiodic chain of building blocks. Modern digital computers use bits as the building blocks, but in general the choice of building blocks depends on the nature of the information to be encoded. What are the optimal building blocks to encode structural information? This can be analysed by substituting the operations of addition and multiplication of conventional arithmetic with translation and rotation. It is argued that at the molecular level, the best component for encoding discretized structural information is carbon. Living organisms discovered this billions of years ago, and used carbon as the back-bone for constructing proteins that function according to their structure. Structural analysis of polypeptide chains shows that an efficient and versatile structural language of 20 building blocks is needed to implement all the tasks carried out by proteins. Properties of amino acids indicate that the present triplet genetic code was preceded by a more primitive one, coding for 10 amino acids using two nucleotide bases.

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Year:  2002        PMID: 12089470     DOI: 10.1007/bf02704910

Source DB:  PubMed          Journal:  J Biosci        ISSN: 0250-5991            Impact factor:   1.826


  9 in total

Review 1.  Origins of gene, genetic code, protein and life: comprehensive view of life systems from a GNC-SNS primitive genetic code hypothesis.

Authors:  K Ikehara
Journal:  J Biosci       Date:  2002-03       Impact factor: 1.826

2.  Stereochemistry of polypeptide chain configurations.

Authors:  G N RAMACHANDRAN; C RAMAKRISHNAN; V SASISEKHARAN
Journal:  J Mol Biol       Date:  1963-07       Impact factor: 5.469

Review 3.  Structural and functional considerations of the aminoacylation reaction.

Authors:  J G Arnez; D Moras
Journal:  Trends Biochem Sci       Date:  1997-06       Impact factor: 13.807

4.  Local rules for protein folding on a triangular lattice and generalized hydrophobicity in the HP model.

Authors:  R Agarwala; S Batzoglou; V Dancík; S E Decatur; S Hannenhalli; M Farach; S Muthukrishnan; S Skiena
Journal:  J Comput Biol       Date:  1997       Impact factor: 1.479

5.  Lattice and off-lattice side chain models of protein folding: linear time structure prediction better than 86% of optimal.

Authors:  W E Hart; S Istrail
Journal:  J Comput Biol       Date:  1997       Impact factor: 1.479

6.  The origin of the genetic code.

Authors:  F H Crick
Journal:  J Mol Biol       Date:  1968-12       Impact factor: 5.469

7.  Obligatory amino acids in primitive proteins.

Authors:  A S Kolaskar; V Ramabrahmam
Journal:  Biosystems       Date:  1982       Impact factor: 1.973

8.  Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs.

Authors:  G Eriani; M Delarue; O Poch; J Gangloff; D Moras
Journal:  Nature       Date:  1990-09-13       Impact factor: 49.962

9.  Codon--anticodon pairing: the wobble hypothesis.

Authors:  F H Crick
Journal:  J Mol Biol       Date:  1966-08       Impact factor: 5.469

  9 in total

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