Literature DB >> 12089281

Evaluation of the C6 peptide enzyme-linked immunosorbent assay for individuals vaccinated with the recombinant OspA vaccine.

Adriana R Marques1, Dale S Martin, Mario T Philipp.   

Abstract

The C6 enzyme-linked immunosorbent assay (ELISA), based on a peptide (C6) that reproduces the sequence of invariable region 6 of VlsE, the antigenic variation protein of Borrelia burgdorferi, has been shown to be a sensitive and specific test for the serologic diagnosis of Lyme disease. We now report that none of 29 uninfected individuals vaccinated with the recombinant OspA vaccine had an antibody response to the C6 peptide. The C6 peptide ELISA can be used to diagnose Lyme disease in patients who have received the OspA vaccine.

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Year:  2002        PMID： 12089281      PMCID： PMC120591          DOI： 10.1128/JCM.40.7.2591-2593.2002

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  15 in total

1.  Effects of OspA vaccination on Lyme disease serologic testing.

Authors:  M E Aguero-Rosenfeld; J Roberge; C A Carbonaro; J Nowakowski; R B Nadelman; G P Wormser
Journal:  J Clin Microbiol       Date:  1999-11       Impact factor: 5.948

2.  Antigenic conservation of an immunodominant invariable region of the VlsE lipoprotein among European pathogenic genospecies of Borrelia burgdorferi SL.

Authors:  F T Liang; E Aberer; M Cinco; L Gern; C M Hu; Y N Lobet; M Ruscio; P E Voet; V E Weynants; M T Philipp
Journal:  J Infect Dis       Date:  2000-10-09       Impact factor: 5.226

3.  Evaluation of whole-cell and OspC enzyme-linked immunosorbent assays for discrimination of early lyme borreliosis from OspA vaccination.

Authors:  C A Wieneke; S D Lovrich; S M Callister; D A Jobe; J A Marks; R F Schell
Journal:  J Clin Microbiol       Date:  2000-01       Impact factor: 5.948

4.  Borrelia burgdorferi enzyme-linked immunosorbent assay for discrimination of OspA vaccination from spirochete infection.

Authors:  Y Q Zhang; D Mathiesen; C P Kolbert; J Anderson; R T Schoen; E Fikrig; D H Persing
Journal:  J Clin Microbiol       Date:  1997-01       Impact factor: 5.948

5.  Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  1995-08-11       Impact factor: 17.586

6.  Immunoblot interpretation criteria for serodiagnosis of early Lyme disease.

Authors:  S M Engstrom; E Shoop; R C Johnson
Journal:  J Clin Microbiol       Date:  1995-02       Impact factor: 5.948

7.  Effect of immunization with recombinant OspA on serologic tests for Lyme borreliosis.

Authors:  P T Fawcett; C D Rose; S M Budd; K M Gibney
Journal:  Clin Diagn Lab Immunol       Date:  2001-01

8.  An immunodominant conserved region within the variable domain of VlsE, the variable surface antigen of Borrelia burgdorferi.

Authors:  F T Liang; A L Alvarez; Y Gu; J M Nowling; R Ramamoorthy; M T Philipp
Journal:  J Immunol       Date:  1999-11-15       Impact factor: 5.422

9.  Detection of multiple reactive protein species by immunoblotting after recombinant outer surface protein A lyme disease vaccination.

Authors:  P J Molloy; V P Berardi; D H Persing; L H Sigal
Journal:  Clin Infect Dis       Date:  2000-07-17       Impact factor: 9.079

10.  Characterization of a Borrelia burgdorferi VlsE invariable region useful in canine Lyme disease serodiagnosis by enzyme-linked immunosorbent assay.

Authors:  F T Liang; R H Jacobson; R K Straubinger; A Grooters; M T Philipp
Journal:  J Clin Microbiol       Date:  2000-11       Impact factor: 5.948
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  7 in total

1.  A decline in C6 antibody titer occurs in successfully treated patients with culture-confirmed early localized or early disseminated Lyme Borreliosis.

Authors:  Mario T Philipp; Gary P Wormser; Adriana R Marques; Susan Bittker; Dale S Martin; John Nowakowski; Leonard G Dally
Journal:  Clin Diagn Lab Immunol       Date:  2005-09

2.  Evaluation of the recombinant VlsE-based liaison chemiluminescence immunoassay for detection of Borrelia burgdorferi and diagnosis of Lyme disease.

Authors:  Thomas B Ledue; Marilyn F Collins; John Young; Martin E Schriefer
Journal:  Clin Vaccine Immunol       Date:  2008-10-22

Review 3.  Laboratory diagnosis of Lyme disease: advances and challenges.

Authors:  Adriana R Marques
Journal:  Infect Dis Clin North Am       Date:  2015-06       Impact factor: 5.982

4.  Occurrence of Dirofilaria immitis and tick-borne infections caused by Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato and Ehrlichia canis in domestic dogs in France: results of a countrywide serologic survey.

Authors:  Nikola Pantchev; Roland Schaper; Sandy Limousin; Nina Norden; Miriam Weise; Leif Lorentzen
Journal:  Parasitol Res       Date:  2009-08       Impact factor: 2.289

Review 5.  Lyme disease.

Authors:  Patricia K Coyle
Journal:  Curr Neurol Neurosci Rep       Date:  2002-11       Impact factor: 5.081

6.  Sensitivity and specificity of a commercial C6 peptide enzyme immuno assay in diagnosis of acute Lyme neuroborreliosis.

Authors:  T Skarpaas; U Ljøstad; M Søbye; A Mygland
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2007-09       Impact factor: 3.267

7.  Canine and human infection with Borrelia burgdorferi in the New York City metropolitan area.

Authors:  Brian H Herrin; Melissa J Beall; Xiao Feng; Monica Papeş; Susan E Little
Journal:  Parasit Vectors       Date:  2018-03-20       Impact factor: 3.876
  7 in total

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